Background: Acne, the most common skin disease characterized by comedones, papules, pustules, nodules, and/or cysts, has a prevalence of 90% during adolescence. The pathogenesis of acne vulgaris requires further study based on the pathological and pathophysiological changes in acne. Recent findings and evidence: Adolescence is the period when teenagers have very high nutritional demands. The occurrence of acne during adolescence suggests that the patient is nutritionally deficient or has increased nutritional requirements. Malnutrition of vitamins (niacin) is the most important cause of abnormal metabolism and inflammation. A pellagra diagnosis should focus on the presence of the “3 D’s” (diarrhea, dermatitis and dementia). The clinical features of acne include “3 D’s”: dermatitis (acne, seborrheic dermatitis), dyspepsia, and depression. Patients with acne are frequently associated with abnormal serum lipid profiles and elevated sebum secretion. Foam cells are an important pathological change in acne lesions. Niacin is the only vitamin that promotes the efflux of cholesterol and other lipids from cells and prevents foam cell formation. Foam cells in acne lesions suggest that patients with acne are deficient in niacin. Recently, several studies have reported the efficacy and safety of nicotinamide and niacin for acne treatment. Summary: Based on an analysis of the clinical feature of acne patients, pathological changes in acne lesions and the therapeutic effects of niacin on acne, we propose that acne can be diagnosed as a specific clinical type of pellagra, and niacin is the first choice for the treatment of acne vulgaris.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6) |
| DOI | 10.11648/j.ajcem.20210906.13 |
| Page(s) | 204-208 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Acne, Niacin, Nicotinamide, Pellagra, Vitamin B3
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APA Style
Jiang Hao, Li Changyi. (2021). Acne Vulgaris Is a Special Clinical Type of Pellagra. American Journal of Clinical and Experimental Medicine, 9(6), 204-208. https://doi.org/10.11648/j.ajcem.20210906.13
ACS Style
Jiang Hao; Li Changyi. Acne Vulgaris Is a Special Clinical Type of Pellagra. Am. J. Clin. Exp. Med. 2021, 9(6), 204-208. doi: 10.11648/j.ajcem.20210906.13
AMA Style
Jiang Hao, Li Changyi. Acne Vulgaris Is a Special Clinical Type of Pellagra. Am J Clin Exp Med. 2021;9(6):204-208. doi: 10.11648/j.ajcem.20210906.13
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Download@article{10.11648/j.ajcem.20210906.13,
author = {Jiang Hao and Li Changyi},
title = {Acne Vulgaris Is a Special Clinical Type of Pellagra},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {9},
number = {6},
pages = {204-208},
doi = {10.11648/j.ajcem.20210906.13},
url = {https://doi.org/10.11648/j.ajcem.20210906.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.13},
abstract = {Background: Acne, the most common skin disease characterized by comedones, papules, pustules, nodules, and/or cysts, has a prevalence of 90% during adolescence. The pathogenesis of acne vulgaris requires further study based on the pathological and pathophysiological changes in acne. Recent findings and evidence: Adolescence is the period when teenagers have very high nutritional demands. The occurrence of acne during adolescence suggests that the patient is nutritionally deficient or has increased nutritional requirements. Malnutrition of vitamins (niacin) is the most important cause of abnormal metabolism and inflammation. A pellagra diagnosis should focus on the presence of the “3 D’s” (diarrhea, dermatitis and dementia). The clinical features of acne include “3 D’s”: dermatitis (acne, seborrheic dermatitis), dyspepsia, and depression. Patients with acne are frequently associated with abnormal serum lipid profiles and elevated sebum secretion. Foam cells are an important pathological change in acne lesions. Niacin is the only vitamin that promotes the efflux of cholesterol and other lipids from cells and prevents foam cell formation. Foam cells in acne lesions suggest that patients with acne are deficient in niacin. Recently, several studies have reported the efficacy and safety of nicotinamide and niacin for acne treatment. Summary: Based on an analysis of the clinical feature of acne patients, pathological changes in acne lesions and the therapeutic effects of niacin on acne, we propose that acne can be diagnosed as a specific clinical type of pellagra, and niacin is the first choice for the treatment of acne vulgaris.},
year = {2021}
}
TY - JOUR T1 - Acne Vulgaris Is a Special Clinical Type of Pellagra AU - Jiang Hao AU - Li Changyi Y1 - 2021/11/24 PY - 2021 N1 - https://doi.org/10.11648/j.ajcem.20210906.13 DO - 10.11648/j.ajcem.20210906.13 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 204 EP - 208 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20210906.13 AB - Background: Acne, the most common skin disease characterized by comedones, papules, pustules, nodules, and/or cysts, has a prevalence of 90% during adolescence. The pathogenesis of acne vulgaris requires further study based on the pathological and pathophysiological changes in acne. Recent findings and evidence: Adolescence is the period when teenagers have very high nutritional demands. The occurrence of acne during adolescence suggests that the patient is nutritionally deficient or has increased nutritional requirements. Malnutrition of vitamins (niacin) is the most important cause of abnormal metabolism and inflammation. A pellagra diagnosis should focus on the presence of the “3 D’s” (diarrhea, dermatitis and dementia). The clinical features of acne include “3 D’s”: dermatitis (acne, seborrheic dermatitis), dyspepsia, and depression. Patients with acne are frequently associated with abnormal serum lipid profiles and elevated sebum secretion. Foam cells are an important pathological change in acne lesions. Niacin is the only vitamin that promotes the efflux of cholesterol and other lipids from cells and prevents foam cell formation. Foam cells in acne lesions suggest that patients with acne are deficient in niacin. Recently, several studies have reported the efficacy and safety of nicotinamide and niacin for acne treatment. Summary: Based on an analysis of the clinical feature of acne patients, pathological changes in acne lesions and the therapeutic effects of niacin on acne, we propose that acne can be diagnosed as a specific clinical type of pellagra, and niacin is the first choice for the treatment of acne vulgaris. VL - 9 IS - 6 ER -
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