Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO

Shan Tiantian; Cheng Zhen; Zuo Erdong; Yan Min; Pan Xiangtao

doi:doi:10.11648/j.ajcem.20210906.11

| Peer-Reviewed

Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO

Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao

Published in American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)

Received: 18 October 2021 Accepted: 9 November 2021 Published: 12 November 2021

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, P<0.05). The cases of anemia before and after radiotherapy were 146 cases and 175 cases (χ²=4.09, P<0.05). (2) The HB level before and after radiotherapy in 92 patients and in 20 cases of control group were respectively 127.33±17.12, 119.41±17.05 and 132.80±11.80g/L, the difference was statistically significant (F=11.70, P<0.01). The anemia cases were 14 and 27, respectively, which were also statistically significant (χ²=8.68, P<0.01). (3) The HEP level before and after radiotherapy in 92 patients and in 20 cases of control group were 3.38±2.48, 2.37±1.37 and 3.22±1.10mg/mL respectively, the difference was statistically significant (F=3.88, P<0.05). (4) EPO level before and after radiotherapy in 92 patients and in 20 controls were 5.05±3.50, 5.75±1.99 and 3.81±1.15mg/mL respectively, the difference was statistically significant (F=9.18, P<0.01). (5) The levels of ALB and PA before radiotherapy in 92 patients were higher than those after radiotherapy. (6) HEP was negatively correlated with HB before radiotherapy (r=-0.2938, t=2.9089, P<0.01), but HEP was not correlated with HB after radiotherapy (r=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all P<0.01). (8) There were positive correlation between PA and HB before and after radiotherapy (all P<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.

Published in	American Journal of Clinical and Experimental Medicine (Volume 9, Issue 6)
DOI	10.11648/j.ajcem.20210906.11
Page(s)	183-186
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Radiotherapy, Anemia, Hepcidin, Erythropoietin (EPO), Tumor, Albumin, Prealbumin

References

[1]	Nemeth E, Ganz T. Hematology-Oncology Clinics of North America. Anemia of inflammation [J] 2014; 28 (4): 671-681.
[2]	Barbra J Sasu, Hongyan Li, Rose MJ. Serum hepcidin but not prohepcidin may be an effective marker for anemia of inflammation. Blood Cells Mol Dis [J] 2010; 45 (3): 238-245.
[3]	Tomas Ganz, Gordana Olbina, Girelli D. Immunoassay for human serum hepcidin. Blood [J] 2008; 112 (10): 4292-4297.
[4]	Saman Shahid. Review of hematological indices of cancer patients receiving combined chemotherapy & radiotherapy or receiving radiotherapy alone [J]. Critical Reviews in Oncology/Hematology, 2016, 105: 145-155.
[5]	Diana A. R. Julie; Jung Hun Oh; Predictors of acute toxicities during definitive chemoradiation using intensity-modulated radiotherapy for anal squamous cell carcinoma [J]. Acta Oncologica, 2016, 55 (2): 208-216.
[6]	Fukuda H, Takekuma M, Hirashima Y. Vitamin B12 deficiency anemia and polyneuropathy due to chronic radiation enteritis [J]. Internal Medicine, 2019, 11 (18): 3695-3699.
[7]	Maria T, Vasileios K. Changes of acute-phase protein levels in the serum of lung cancer patients following radiotherapy [J]. Inter J Clinic and Exper, 2013, 6 (1): 50-60.
[8]	H Y Kwon, B R Kim, Kim YW. Association of preoperative anemia and perioperative allogenic red blood cell transfusion with oncologic outcomes in patients with nonmetastatic colorectal cancer. Curr Oncol [J] 2019; 26 (3): e357-e366.
[9]	ZHAO Lingqin, ZHANG Yingli, FANG Chenyan, et al. Investigation on anemia and its treatment status in patients with cervical cancer undergoing radiotherapy and chemotherapy. Modern Chinese Medicine [J]. 2019, 57 (16): 131-135.
[10]	Yong Wang, Virginia Probin, Zhou D. Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy. Curr Cancer Ther Rev [J] 2006; 2 (3): 271-279.
[11]	Hiroyuki Fukuda, Munetaka Takekuma, Hirashima Y. Vitamin B12 Deficiency Anemia and Polyneuropathy Due to Chronic Radiation Enteritis. Intern Med. 59 [J] 2020; (6): 859-861.
[12]	Abdelfattah, B., Buck, T. and Byram, S. (2014) Epidural Hematoma after the Use of Subcutaneous Unfractionated Heparin and History of Epidural Tumor. Open Journal of Anesthesiology. 4, 163-166. doi: 10.4236/ojanes.2014.47023.
[13]	D'Angelo G. Role of heocidin in pathophsiology and diagnosis of anemia [J]. Blood Res, 2013, 48 (1): 10-15.
[14]	LU Ye, CHENG Xu, Rong L. The expression and clinical significance of ferroportin and hepcidin in breast cancer patients. The Journal of the Kuwait Medical Association [J] 2016; 48 (4): 323-327.
[15]	Kruttika Bhat, Kiri Sandler, Muggy SD. Serum erythropoietin levels, breast cancer and breast cancer-initiating cells. Breast Cancer Res [J] 2019; 21 (1): 17.

Cite This Article

Plain Text BibTeX RIS

APA Style

Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao. (2021). Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. American Journal of Clinical and Experimental Medicine, 9(6), 183-186. https://doi.org/10.11648/j.ajcem.20210906.11

Copy | Download

ACS Style

Shan Tiantian; Cheng Zhen; Zuo Erdong; Yan Min; Pan Xiangtao. Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. Am. J. Clin. Exp. Med. 2021, 9(6), 183-186. doi: 10.11648/j.ajcem.20210906.11

Copy | Download

AMA Style

Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao. Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. Am J Clin Exp Med. 2021;9(6):183-186. doi: 10.11648/j.ajcem.20210906.11

Copy | Download

@article{10.11648/j.ajcem.20210906.11,
  author = {Shan Tiantian and Cheng Zhen and Zuo Erdong and Yan Min and Pan Xiangtao},
  title = {Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {6},
  pages = {183-186},
  doi = {10.11648/j.ajcem.20210906.11},
  url = {https://doi.org/10.11648/j.ajcem.20210906.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.11},
  abstract = {We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, Pχ2=4.09, PF=11.70, Pχ2=8.68, PF=3.88, PF=9.18, Pr=-0.2938, t=2.9089, Pr=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all PP<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO
AU  - Shan Tiantian
AU  - Cheng Zhen
AU  - Zuo Erdong
AU  - Yan Min
AU  - Pan Xiangtao
Y1  - 2021/11/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210906.11
DO  - 10.11648/j.ajcem.20210906.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 183
EP  - 186
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210906.11
AB  - We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, Pχ2=4.09, PF=11.70, Pχ2=8.68, PF=3.88, PF=9.18, Pr=-0.2938, t=2.9089, Pr=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all PP<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.
VL  - 9
IS  - 6
ER  -

Copy | Download

Author Information

Shan Tiantian

Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China
Cheng Zhen

Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China
Zuo Erdong

Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China
Yan Min

Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China
Pan Xiangtao

Department of Hematology, Taicang Hospital of Soochow University, Taicang City, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao. (2021). Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. American Journal of Clinical and Experimental Medicine, 9(6), 183-186. https://doi.org/10.11648/j.ajcem.20210906.11

Copy | Download

ACS Style

Shan Tiantian; Cheng Zhen; Zuo Erdong; Yan Min; Pan Xiangtao. Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. Am. J. Clin. Exp. Med. 2021, 9(6), 183-186. doi: 10.11648/j.ajcem.20210906.11

Copy | Download

AMA Style

Shan Tiantian, Cheng Zhen, Zuo Erdong, Yan Min, Pan Xiangtao. Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO. Am J Clin Exp Med. 2021;9(6):183-186. doi: 10.11648/j.ajcem.20210906.11

Copy | Download

@article{10.11648/j.ajcem.20210906.11,
  author = {Shan Tiantian and Cheng Zhen and Zuo Erdong and Yan Min and Pan Xiangtao},
  title = {Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {9},
  number = {6},
  pages = {183-186},
  doi = {10.11648/j.ajcem.20210906.11},
  url = {https://doi.org/10.11648/j.ajcem.20210906.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20210906.11},
  abstract = {We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, Pχ2=4.09, PF=11.70, Pχ2=8.68, PF=3.88, PF=9.18, Pr=-0.2938, t=2.9089, Pr=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all PP<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Effect of Radiotherapy on HB Level and Nutritional Status of Tumor Patients and Its Relationship with Hepcidin and EPO
AU  - Shan Tiantian
AU  - Cheng Zhen
AU  - Zuo Erdong
AU  - Yan Min
AU  - Pan Xiangtao
Y1  - 2021/11/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ajcem.20210906.11
DO  - 10.11648/j.ajcem.20210906.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 183
EP  - 186
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20210906.11
AB  - We studied the expression features of Hepcidin (HEP), Erythropoietin (EPO), Albumin (ALB) and Prealbumin (PA), and the pathogenesis of anemia in tumor patients caused by radiotherapy. We tested the hemoglobin (HB) concentration in 446 cancer patients who received radiotherapy, and measured the serum HEP, EPO, ALB and PA n 92 cases to explore the pathogenesis of anemia caused by radiotherapy. The results were: (1) The HB level before and after radiotherapy in 446 patients were 119.85±19.87g/L and 116.32±24.25g/L (t=2.5211, Pχ2=4.09, PF=11.70, Pχ2=8.68, PF=3.88, PF=9.18, Pr=-0.2938, t=2.9089, Pr=- 0.0111, P>0.05). (7) There were positive correlation between ALB and HB before and after radiotherapy (all PP<0.01). Therefore, Radiotherapy could cause anemia and deteriorate nutritional status in cancer patients. Anemia negatively feedback inhibited the expression of HEP, while EPO was highly compensatory.
VL  - 9
IS  - 6
ER  -

Copy | Download