@article{10.11648/j.ajcem.20190706.13,
  author = {Xu Jianxing},
  title = {Idea on Holistic Medicine Based on the Electron Leak Pathways of Mitochondrial Respiratory Chain},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {7},
  number = {6},
  pages = {135-142},
  doi = {10.11648/j.ajcem.20190706.13},
  url = {https://doi.org/10.11648/j.ajcem.20190706.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20190706.13},
  abstract = {With the development of physical technology, life science has reached the molecular level. With the development of molecular biology, western medicine has carried out in-depth analysis and Experimental Research on diseases. Nevertheless, wise thinking about the theory and current situation of Western medicine can still find some problems worth to investigation. With the breakthroughs in cell and molecular biology, protein function and gene regulation have become the starting point and theoretical basis for thinking about medical problems and developing drugs. However, the human body is a multicellular organism, which is the coordination of multiple functional organs formed by orderly accumulation of cells. At present, the knowledge of molecular biology on the orderly accumulation of cells is still scarce in life science. This knowledge black hole makes Western medicine far from being based on a comprehensive understanding on the human body, thus making the scientific nature of Western medicine imperfect. Mitochondrial symbiosis is a landmark event in which life evolves from a single cell to a multicellular one. In our lab the discovery of electron leak pathways of the mitochondrial respiratory chain reminds me to describe the function of respiratory chain as the molecular "life-engine". The role of ROS generated in mitochondria through the electron leak pathways of the respiratory chain has become a new investigative field of health and longevity. The signal effect of ROS on antioxidant activity and tissue repair activity has become a hotspot in medical research. An idea to explore medical problems in perspective of bioenergetics came into being in my mind. In 2016, I published a paper in the Journal of clinical and experimental cardiology, which suggested that the human body should be regarded as a whole composed of a huge number of "life engines", and human health and medicine should be studied with thermodynamics. A big question is that the ROS generated by the electron leakage of respiratory chain has two opposite roles: it causes aging and diseases by the oxygen toxicity of ROS and it role as signal to stimulate antioxidative activity or tissue repair ability. Then how the human body makes decision to tell ROS play as a positive or negative role? Answering this question takes me long time searching. In this paper, I will elaborate on this issue from the perspective of cosmic energetics.},
 year = {2019}
}

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TY  - JOUR
T1  - Idea on Holistic Medicine Based on the Electron Leak Pathways of Mitochondrial Respiratory Chain
AU  - Xu Jianxing
Y1  - 2019/12/13
PY  - 2019
N1  - https://doi.org/10.11648/j.ajcem.20190706.13
DO  - 10.11648/j.ajcem.20190706.13
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 135
EP  - 142
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20190706.13
AB  - With the development of physical technology, life science has reached the molecular level. With the development of molecular biology, western medicine has carried out in-depth analysis and Experimental Research on diseases. Nevertheless, wise thinking about the theory and current situation of Western medicine can still find some problems worth to investigation. With the breakthroughs in cell and molecular biology, protein function and gene regulation have become the starting point and theoretical basis for thinking about medical problems and developing drugs. However, the human body is a multicellular organism, which is the coordination of multiple functional organs formed by orderly accumulation of cells. At present, the knowledge of molecular biology on the orderly accumulation of cells is still scarce in life science. This knowledge black hole makes Western medicine far from being based on a comprehensive understanding on the human body, thus making the scientific nature of Western medicine imperfect. Mitochondrial symbiosis is a landmark event in which life evolves from a single cell to a multicellular one. In our lab the discovery of electron leak pathways of the mitochondrial respiratory chain reminds me to describe the function of respiratory chain as the molecular "life-engine". The role of ROS generated in mitochondria through the electron leak pathways of the respiratory chain has become a new investigative field of health and longevity. The signal effect of ROS on antioxidant activity and tissue repair activity has become a hotspot in medical research. An idea to explore medical problems in perspective of bioenergetics came into being in my mind. In 2016, I published a paper in the Journal of clinical and experimental cardiology, which suggested that the human body should be regarded as a whole composed of a huge number of "life engines", and human health and medicine should be studied with thermodynamics. A big question is that the ROS generated by the electron leakage of respiratory chain has two opposite roles: it causes aging and diseases by the oxygen toxicity of ROS and it role as signal to stimulate antioxidative activity or tissue repair ability. Then how the human body makes decision to tell ROS play as a positive or negative role? Answering this question takes me long time searching. In this paper, I will elaborate on this issue from the perspective of cosmic energetics.
VL  - 7
IS  - 6
ER  - 

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