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Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital

Received: 23 April 2019     Accepted: 10 June 2019     Published: 26 June 2019
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Abstract

Hyponatremia is recognized as the most common electrolyte disorder in hospitalization services. It is associated in the literature with a prolongation of the hospitalization with a variable mortality according to comorbidities and etiologies. In Togo, although empirically noted, this excess mortality has never been demonstrated. The objective of our study was to determine the survival and mortality of patients with hyponatremia in the intensive care units of the Sylvanus Olympio Hospital Center (CHU SO). We collected 2802 patients over the period from January 1, 2015 to December 31, 2016. Of these patients, 327 included patients, of whom 79 had hyponatremia, had a frequency of 23.6%. The prevalence of hyponatremia was 2.8%. The average of natremia was 126.3 ± 6.8 mmol/L with extremes of 100 mmol/L and 134 mmol/L. The mean age of patients was 52.3 ± 18.2 years (range: 18 to 92 years) with a sex ratio (M / F) of 1.5. The most common comorbidities were high blood pressure (32.9%) and diabetes (13.9%). The most common etiology was neurological (26.6%), renal (20.3%) and infectious (19%). The average duration of hospitalization was 11 days. The probability of survival after 11 days was 49%, with excess mortality depending on the severity of hyponatremia. Because of its importance hyponatremia appears as a cause of mortality. This study provides the prognosis of patients in intensive care and urges the implementation of ionogram monitoring technique.

Published in American Journal of Clinical and Experimental Medicine (Volume 7, Issue 1)
DOI 10.11648/j.ajcem.20190701.15
Page(s) 35-41
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hyponatremia, Epidemiology, Mortality, Survival, Sub-saharan Africa

References
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[3] Passeron A, Dupeux S, Blanchard A. Hyponatrémie: de la physiopathologie à la pratique. Rev Médecine Interne. 2010; 31 (4): 277–286.
[4] Langlois PL, Bourguignon MJ, Manzanares W. L’hyponatrémie chez le patient cérébrolésé en soins intensifs: étiologie et prise en charge. Médecine Intensive Réanimation. 2016; 25 (5): 203–213.
[5] Olsson K, Öhlin B, Melander O. Epidemiology and characteristics of hyponatremia in the emergency department. Eur J Intern Med. 1 mars 2013; 24 (2): 110-6.
[6] Tamizifar B, Kheiry S, Fereidoony F. Hyponatremia and 30 days mortality of patients with acute pulmonary embolism. J Res Med Sci Off J Isfahan Univ Med Sci. août 2015; 20 (8): 777-81.
[7] Bennani SL, Abouqal R, Zeggwagh AA, Madani N, Abidi K, Zekraoui A, et al. Incidence, causes and prognostic factors of hyponatremia in intensive care. Rev Med Interne. 2003; 24 (4): 224–229.
[8] Hao J, Li Y, Zhang X, Pang C, Wang Y, Nigwekar SU, et al. The prevalence and mortality of hyponatremia is seriously underestimated in Chinese general medical patients: an observational retrospective study. BMC Nephrol. 31 oct 2017; 18 (1): 328.
[9] Eckart A, Hausfater P, Amin D, Amin A, Haubitz S, Bernard M, et al. Hyponatremia and activation of vasopressin secretion are both independently associated with 30-day mortality: results of a multicenter, observational study. J Intern Med. 2018.
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[16] Chalela R, González-García JG, Chillarón JJ, Valera-Hernández L, Montoya-Rangel C, Badenes D, et al. Impact of hyponatremia on mortality and morbidity in patients with COPD exacerbations. Respir Med. 2016; 117: 237-42.
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  • APA Style

    Eyram Yoan Makafui Amekoudi, Kossi Akomola Sabi, Komlan Georges Tona, Badomta Dolaama, Béfa Noto-Kadou-Kaza, et al. (2019). Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital. American Journal of Clinical and Experimental Medicine, 7(1), 35-41. https://doi.org/10.11648/j.ajcem.20190701.15

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    ACS Style

    Eyram Yoan Makafui Amekoudi; Kossi Akomola Sabi; Komlan Georges Tona; Badomta Dolaama; Béfa Noto-Kadou-Kaza, et al. Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital. Am. J. Clin. Exp. Med. 2019, 7(1), 35-41. doi: 10.11648/j.ajcem.20190701.15

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    AMA Style

    Eyram Yoan Makafui Amekoudi, Kossi Akomola Sabi, Komlan Georges Tona, Badomta Dolaama, Béfa Noto-Kadou-Kaza, et al. Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital. Am J Clin Exp Med. 2019;7(1):35-41. doi: 10.11648/j.ajcem.20190701.15

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  • @article{10.11648/j.ajcem.20190701.15,
      author = {Eyram Yoan Makafui Amekoudi and Kossi Akomola Sabi and Komlan Georges Tona and Badomta Dolaama and Béfa Noto-Kadou-Kaza and Epiphane Kola and Bayaki Saka},
      title = {Survival and Mortality of Patients with Hyponatremia in Intensive Care Units: A Retrospective Study of 327 Patients Hospitalized at Sylvanus Olympio University Hospital},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {7},
      number = {1},
      pages = {35-41},
      doi = {10.11648/j.ajcem.20190701.15},
      url = {https://doi.org/10.11648/j.ajcem.20190701.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20190701.15},
      abstract = {Hyponatremia is recognized as the most common electrolyte disorder in hospitalization services. It is associated in the literature with a prolongation of the hospitalization with a variable mortality according to comorbidities and etiologies. In Togo, although empirically noted, this excess mortality has never been demonstrated. The objective of our study was to determine the survival and mortality of patients with hyponatremia in the intensive care units of the Sylvanus Olympio Hospital Center (CHU SO). We collected 2802 patients over the period from January 1, 2015 to December 31, 2016. Of these patients, 327 included patients, of whom 79 had hyponatremia, had a frequency of 23.6%. The prevalence of hyponatremia was 2.8%. The average of natremia was 126.3 ± 6.8 mmol/L with extremes of 100 mmol/L and 134 mmol/L. The mean age of patients was 52.3 ± 18.2 years (range: 18 to 92 years) with a sex ratio (M / F) of 1.5. The most common comorbidities were high blood pressure (32.9%) and diabetes (13.9%). The most common etiology was neurological (26.6%), renal (20.3%) and infectious (19%). The average duration of hospitalization was 11 days. The probability of survival after 11 days was 49%, with excess mortality depending on the severity of hyponatremia. Because of its importance hyponatremia appears as a cause of mortality. This study provides the prognosis of patients in intensive care and urges the implementation of ionogram monitoring technique.},
     year = {2019}
    }
    

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    AU  - Eyram Yoan Makafui Amekoudi
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    JF  - American Journal of Clinical and Experimental Medicine
    JO  - American Journal of Clinical and Experimental Medicine
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    PB  - Science Publishing Group
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    AB  - Hyponatremia is recognized as the most common electrolyte disorder in hospitalization services. It is associated in the literature with a prolongation of the hospitalization with a variable mortality according to comorbidities and etiologies. In Togo, although empirically noted, this excess mortality has never been demonstrated. The objective of our study was to determine the survival and mortality of patients with hyponatremia in the intensive care units of the Sylvanus Olympio Hospital Center (CHU SO). We collected 2802 patients over the period from January 1, 2015 to December 31, 2016. Of these patients, 327 included patients, of whom 79 had hyponatremia, had a frequency of 23.6%. The prevalence of hyponatremia was 2.8%. The average of natremia was 126.3 ± 6.8 mmol/L with extremes of 100 mmol/L and 134 mmol/L. The mean age of patients was 52.3 ± 18.2 years (range: 18 to 92 years) with a sex ratio (M / F) of 1.5. The most common comorbidities were high blood pressure (32.9%) and diabetes (13.9%). The most common etiology was neurological (26.6%), renal (20.3%) and infectious (19%). The average duration of hospitalization was 11 days. The probability of survival after 11 days was 49%, with excess mortality depending on the severity of hyponatremia. Because of its importance hyponatremia appears as a cause of mortality. This study provides the prognosis of patients in intensive care and urges the implementation of ionogram monitoring technique.
    VL  - 7
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Author Information
  • Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo

  • Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo

  • Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo

  • Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo

  • Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo

  • Department of Nephrology and Hemodialysis, University of Lome, Lome, Togo

  • Department of Dermatology and Venerology, University of Lome, Lome, Togo

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