Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance

Li Hongyan; Xu Qian; Liu Jing; Li Juan

doi:doi:10.11648/j.ajcem.20190701.14

| Peer-Reviewed

Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance

Li Hongyan, Xu Qian, Liu Jing, Li Juan

Published in American Journal of Clinical and Experimental Medicine (Volume 7, Issue 1)

Received: 18 February 2019 Published: 29 April 2019

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum TC, TG, HDL, LDL, LPa, Hcy and ET. The correlation were analyzed. Results The level of TC, TG, LDL of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group, HDL is lower than the control group. The level of TC, TG, LDL of hyperthyroidism group is higher than subclinical hyperthyroidism group, HDL is lower than subclinical hyperthyroidism group. The level of Hcy of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group. The level of Hcy of hyperthyroidism group is higher than subclinical hyperthyroidism group. The level of ET of hyperthyroidism group is lower than the control group and subclinical hyperthyroidism group. Conclusions All of blood lipids, Hcy and ET participate in the development process of hypothyroidism and subclinical hypothyroidism which is of great value in predicting the transition of thyroid dysfunction and the occurrence of adverse consequences.

Published in	American Journal of Clinical and Experimental Medicine (Volume 7, Issue 1)
DOI	10.11648/j.ajcem.20190701.14
Page(s)	31-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Hypothyroidism, Subclinical Hypothyroidism, Blood Lipids, Hcy, ET

References

[1]	Vanessa S. Virgini, Liselotte W. Wijsman, Nicolas Rodondi, et al. Subclinical Thyroid Dysfunction and Functional Capacity Among Elderly [J]. Thyroid, 2014, 24 (2): 208-214.
[2]	Chen-Hua, Xin-Ning. Clinical efficacy and changes in serum lipid index of levothyroxine in subclinical and clinical hypothyroidism [J]. Chinese Journal of Clinical Research, 2014, 6 (9):84
[3]	Wiles KS, Jarvis S, Nelson-Piercy C. Are we overtreating subclinical hypothyroidism in pregnancy? [J]. BMJ, 2015, 351 h4726.
[4]	Chen Xiao-fang, Xu-Bo, Feng-Kai, et al. Study on endothelin, fibrinogen and lipid levels in subclinical hypothyroidism [J]. International Journal of Laboratory Medicine, 2012, 33 (23):2828-2829.
[5]	Shi Qing-jun, Dai li-li. Changes of serum resistin and homocysteine levels in patients with subclinical hypothyroidism [J]. Chinese Journal of Gerontology, 2017, 37 (15):3765-3766.
[6]	Guo Juan-juan. Effects of levothyroxine sodium combined with thyroid tablets on thyroid hormone changes in elderly patients with hypothyroidism [J]. Frontier of Medicine, 2017, 07 (13):132-133.
[7]	Pan Yan-hui, Sun Yun-peng, Zhang-Wei. Effects of levothyroxine sodium combined with thyroid tablets on thyroid function and blood lipids in patients with hypothyroidism [J]. Women's Health Research, 2018 (14):39-40.
[8]	Ren Yun-xia, Zhang Jun-qi, Fan Chun-yu. Clinical characteristics and prognosis of patients with coronary heart disease complicated with subclinical hypothyroidism [J]. Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease, 2018, 16 (10):1381-1384.
[9]	Gong Ning-ning, Gong Ting-ting. Research progress on blood lipid level in subclinical hypothyroidism [J]. Scientific & Technical Information of Gansu, 2018, 47 (05):81-85.
[10]	Wu Peng-fei, Dong-Zhen. The relationship between hypothyroidism and serum levels of total homocysteine, lipid and endothelin [J]. Journal of Bethune Military Medical College, 2013, 11 (06):508-509.
[11]	Zhou-Hui, Li Peng-qiu, Liu Li-mei, et al. Study on TSH and dyslipidemia in subclinical hypothyroidism [J]. Journal of China Prescription Drug, 2018, 16 (02):7-8.
[12]	Qi Ying-ying. Clinical Significance of Combined Detection of Lipoprotein Alpha, Homocysteine and Routine Blood Lipids in Atherosclerosis [J]. China Medical Engineering, 2018, 26 (4): 51－53.
[13]	Hu Yao-shi, Zeng Zhi-yu. Research Progress on the Relationship between Homocysteine and Common Clinical Diseases [J]. Chinese Journal of New Clinical Medicine, 2017, 10 (08):811-815.
[14]	Guan Shi-kui, Liu-Zheng, Zhang Fa-sheng, et al. Mete analysis of the relationship between serum cystatin C level and coronary heart disease [J]. Labeled Immunoassays and Clinical Medicine, 2015, 22 (10): 994-997.
[15]	Chi Xin-dong, Ma-Li, He-Jia, et al. Diagnostic value of combined detection of homocysteine (Hcy), serum cystatin C (CysC) and urinary microalbumin (U-Malb) for early renal injury in hypertension [J]. Chinese Journal of Laboratory diagnosis, 2017, 21 (6): 939-941.
[16]	Hou Zhen-jiang, Mou Zhao-xin, Zhang Jing-yu, et al. The clinical significance in teseing serum cystatin C and homocysteine of subclinical thyroid dysfunction [J]. Medicine & Philosophy (B), 2017, 38 (08):40-44.
[17]	Yu-Yang, Chen Hui-yong, Sun-Chao. Effects of Danhong injection on C-reactive protein and homocysteine of patients with early lower extremity arteriosclerosis obliteran [J/OL]. World Chinese Medicine, 2018 (04):909-914
[18]	Chen-Na. The effect of folic acid and Mecobenamine on 41 patients with acute cerebral infarction with high homocysteine [J]. Contemporary medicine, 2018, 24 (13): 72-74.
[19]	Dai Li-li, Liu Jia-jia, Mi Yu-jing et al, Study on the correlation between subclinical thyroid dysfunction and serum resistin and homocysteine [J]. Chinese Journal of Health laboratory Technology, 2015, 25 (14):2346-2348.
[20]	Wei-Yan, Jie Jia-mei, Shi Li-xin. The metabolic characteristics of lipid profile and homocysteine in the patients with subclinical hypothyroidism [J]. International Journal of Laboratory Medicine, 2013, 34 (24):3330-3331+3334.
[21]	Zhu ya-lin, Huo-ying, Pan yun-long. Clinical significance of plasma atrial natriuretic factor and endothelin detection in hyperthyroidism and hypothyroidism [J]. Labeled Immunoassays and Clinical Medicine, 2005 (01):13-14+3.

Cite This Article

Plain Text BibTeX RIS

APA Style

Li Hongyan, Xu Qian, Liu Jing, Li Juan. (2019). Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance. American Journal of Clinical and Experimental Medicine, 7(1), 31-34. https://doi.org/10.11648/j.ajcem.20190701.14

Copy | Download

ACS Style

Li Hongyan; Xu Qian; Liu Jing; Li Juan. Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance. Am. J. Clin. Exp. Med. 2019, 7(1), 31-34. doi: 10.11648/j.ajcem.20190701.14

Copy | Download

AMA Style

Li Hongyan, Xu Qian, Liu Jing, Li Juan. Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance. Am J Clin Exp Med. 2019;7(1):31-34. doi: 10.11648/j.ajcem.20190701.14

Copy | Download

@article{10.11648/j.ajcem.20190701.14,
  author = {Li Hongyan and Xu Qian and Liu Jing and Li Juan},
  title = {Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {7},
  number = {1},
  pages = {31-34},
  doi = {10.11648/j.ajcem.20190701.14},
  url = {https://doi.org/10.11648/j.ajcem.20190701.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20190701.14},
  abstract = {Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum TC, TG, HDL, LDL, LPa, Hcy and ET. The correlation were analyzed. Results The level of TC, TG, LDL of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group, HDL is lower than the control group. The level of TC, TG, LDL of hyperthyroidism group is higher than subclinical hyperthyroidism group, HDL is lower than subclinical hyperthyroidism group. The level of Hcy of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group. The level of Hcy of hyperthyroidism group is higher than subclinical hyperthyroidism group. The level of ET of hyperthyroidism group is lower than the control group and subclinical hyperthyroidism group. Conclusions All of blood lipids, Hcy and ET participate in the development process of hypothyroidism and subclinical hypothyroidism which is of great value in predicting the transition of thyroid dysfunction and the occurrence of adverse consequences.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance
AU  - Li Hongyan
AU  - Xu Qian
AU  - Liu Jing
AU  - Li Juan
Y1  - 2019/04/29
PY  - 2019
N1  - https://doi.org/10.11648/j.ajcem.20190701.14
DO  - 10.11648/j.ajcem.20190701.14
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 31
EP  - 34
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20190701.14
AB  - Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum TC, TG, HDL, LDL, LPa, Hcy and ET. The correlation were analyzed. Results The level of TC, TG, LDL of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group, HDL is lower than the control group. The level of TC, TG, LDL of hyperthyroidism group is higher than subclinical hyperthyroidism group, HDL is lower than subclinical hyperthyroidism group. The level of Hcy of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group. The level of Hcy of hyperthyroidism group is higher than subclinical hyperthyroidism group. The level of ET of hyperthyroidism group is lower than the control group and subclinical hyperthyroidism group. Conclusions All of blood lipids, Hcy and ET participate in the development process of hypothyroidism and subclinical hypothyroidism which is of great value in predicting the transition of thyroid dysfunction and the occurrence of adverse consequences.
VL  - 7
IS  - 1
ER  -

Copy | Download

Author Information

Li Hongyan

Department of Medical Technology of Cangzhou Medical College, Cangzhou, China
Xu Qian

Department of Medical Technology of Cangzhou Medical College, Cangzhou, China
Liu Jing

Laboratory Department of Cangzhou Traditional Chinese Medicine-Western Hospital, Cangzhou, China
Li Juan

Laboratory Department of Cangzhou Traditional Chinese Medicine-Western Hospital, Cangzhou, China

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Li Hongyan, Xu Qian, Liu Jing, Li Juan. (2019). Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance. American Journal of Clinical and Experimental Medicine, 7(1), 31-34. https://doi.org/10.11648/j.ajcem.20190701.14

Copy | Download

ACS Style

Li Hongyan; Xu Qian; Liu Jing; Li Juan. Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance. Am. J. Clin. Exp. Med. 2019, 7(1), 31-34. doi: 10.11648/j.ajcem.20190701.14

Copy | Download

AMA Style

Li Hongyan, Xu Qian, Liu Jing, Li Juan. Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance. Am J Clin Exp Med. 2019;7(1):31-34. doi: 10.11648/j.ajcem.20190701.14

Copy | Download

@article{10.11648/j.ajcem.20190701.14,
  author = {Li Hongyan and Xu Qian and Liu Jing and Li Juan},
  title = {Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {7},
  number = {1},
  pages = {31-34},
  doi = {10.11648/j.ajcem.20190701.14},
  url = {https://doi.org/10.11648/j.ajcem.20190701.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20190701.14},
  abstract = {Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum TC, TG, HDL, LDL, LPa, Hcy and ET. The correlation were analyzed. Results The level of TC, TG, LDL of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group, HDL is lower than the control group. The level of TC, TG, LDL of hyperthyroidism group is higher than subclinical hyperthyroidism group, HDL is lower than subclinical hyperthyroidism group. The level of Hcy of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group. The level of Hcy of hyperthyroidism group is higher than subclinical hyperthyroidism group. The level of ET of hyperthyroidism group is lower than the control group and subclinical hyperthyroidism group. Conclusions All of blood lipids, Hcy and ET participate in the development process of hypothyroidism and subclinical hypothyroidism which is of great value in predicting the transition of thyroid dysfunction and the occurrence of adverse consequences.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Detection of Blood Lipids, Homocysteine and Endothelin in Patients with Hypothyroidism and Subclinical Hypothyroidism and Its Clinical Significance
AU  - Li Hongyan
AU  - Xu Qian
AU  - Liu Jing
AU  - Li Juan
Y1  - 2019/04/29
PY  - 2019
N1  - https://doi.org/10.11648/j.ajcem.20190701.14
DO  - 10.11648/j.ajcem.20190701.14
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 31
EP  - 34
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20190701.14
AB  - Objective To discuss the changes of blood lipids, homocysteine (Hcy) and endothelin (ET) levels in patients with hypothyroidism and subclinical hypothyroidism, and to explore their clinical significance. Methods The authors choose 255 cases of hypothyroidism, 274 cases of subclinical hypothyroidism and 130 cases of the control group to test serum TC, TG, HDL, LDL, LPa, Hcy and ET. The correlation were analyzed. Results The level of TC, TG, LDL of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group, HDL is lower than the control group. The level of TC, TG, LDL of hyperthyroidism group is higher than subclinical hyperthyroidism group, HDL is lower than subclinical hyperthyroidism group. The level of Hcy of hyperthyroidism group and subclinical hyperthyroidism group are higher than the control group. The level of Hcy of hyperthyroidism group is higher than subclinical hyperthyroidism group. The level of ET of hyperthyroidism group is lower than the control group and subclinical hyperthyroidism group. Conclusions All of blood lipids, Hcy and ET participate in the development process of hypothyroidism and subclinical hypothyroidism which is of great value in predicting the transition of thyroid dysfunction and the occurrence of adverse consequences.
VL  - 7
IS  - 1
ER  -

Copy | Download