Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing <i>Escherichia coli</i> Infection: A Case Report

Takahiro Yukawa; Takuto Ishida; Toshinobu Yamagishi; Kazuhiro Sugiyama; Yuichi Hamabe

doi:doi:10.11648/j.ajcem.20180601.15

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Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report

Takahiro Yukawa, Takuto Ishida, Toshinobu Yamagishi, Kazuhiro Sugiyama, Yuichi Hamabe

Published in American Journal of Clinical and Experimental Medicine (Volume 6, Issue 1)

Received: 12 January 2018 Accepted: 1 February 2018 Published: 8 March 2018

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Abstract

Hemolytic-uremic syndrome (HUS), which is characterized by microvascular hemolytic anemia, consumption thrombocytopenia, and acute renal failure, is a complication of the Shiga-toxin-producing Escherichia coli (STEC) infection. We describe the case of a patient who, despite undergoing plasma exchange and renal replacement therapy for STEC-induced HUS, experienced poor improvement in platelet count, serum creatinine level, and serum lactate dehydrogenase level. The patient developed acute encephalopathy but recovered without permanent organ damage after eculizumab therapy. For severe HUS cases involving the central nervous system, early administration of eculizumab, which inhibits the abnormal activation of the complement activation pathway, may be effective.

Published in	American Journal of Clinical and Experimental Medicine (Volume 6, Issue 1)
DOI	10.11648/j.ajcem.20180601.15
Page(s)	27-32
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Hemolytic-Uremic Syndrome, Shiga-Toxin-Producing Escherichia coli Infection, Acute Encephalopathy, Eculizumab

References

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APA Style

Takahiro Yukawa, Takuto Ishida, Toshinobu Yamagishi, Kazuhiro Sugiyama, Yuichi Hamabe. (2018). Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report. American Journal of Clinical and Experimental Medicine, 6(1), 27-32. https://doi.org/10.11648/j.ajcem.20180601.15

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ACS Style

Takahiro Yukawa; Takuto Ishida; Toshinobu Yamagishi; Kazuhiro Sugiyama; Yuichi Hamabe. Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report. Am. J. Clin. Exp. Med. 2018, 6(1), 27-32. doi: 10.11648/j.ajcem.20180601.15

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AMA Style

Takahiro Yukawa, Takuto Ishida, Toshinobu Yamagishi, Kazuhiro Sugiyama, Yuichi Hamabe. Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report. Am J Clin Exp Med. 2018;6(1):27-32. doi: 10.11648/j.ajcem.20180601.15

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@article{10.11648/j.ajcem.20180601.15,
  author = {Takahiro Yukawa and Takuto Ishida and Toshinobu Yamagishi and Kazuhiro Sugiyama and Yuichi Hamabe},
  title = {Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {6},
  number = {1},
  pages = {27-32},
  doi = {10.11648/j.ajcem.20180601.15},
  url = {https://doi.org/10.11648/j.ajcem.20180601.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20180601.15},
  abstract = {Hemolytic-uremic syndrome (HUS), which is characterized by microvascular hemolytic anemia, consumption thrombocytopenia, and acute renal failure, is a complication of the Shiga-toxin-producing Escherichia coli (STEC) infection. We describe the case of a patient who, despite undergoing plasma exchange and renal replacement therapy for STEC-induced HUS, experienced poor improvement in platelet count, serum creatinine level, and serum lactate dehydrogenase level. The patient developed acute encephalopathy but recovered without permanent organ damage after eculizumab therapy. For severe HUS cases involving the central nervous system, early administration of eculizumab, which inhibits the abnormal activation of the complement activation pathway, may be effective.},
 year = {2018}
}

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TY  - JOUR
T1  - Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report
AU  - Takahiro Yukawa
AU  - Takuto Ishida
AU  - Toshinobu Yamagishi
AU  - Kazuhiro Sugiyama
AU  - Yuichi Hamabe
Y1  - 2018/03/08
PY  - 2018
N1  - https://doi.org/10.11648/j.ajcem.20180601.15
DO  - 10.11648/j.ajcem.20180601.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 27
EP  - 32
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20180601.15
AB  - Hemolytic-uremic syndrome (HUS), which is characterized by microvascular hemolytic anemia, consumption thrombocytopenia, and acute renal failure, is a complication of the Shiga-toxin-producing Escherichia coli (STEC) infection. We describe the case of a patient who, despite undergoing plasma exchange and renal replacement therapy for STEC-induced HUS, experienced poor improvement in platelet count, serum creatinine level, and serum lactate dehydrogenase level. The patient developed acute encephalopathy but recovered without permanent organ damage after eculizumab therapy. For severe HUS cases involving the central nervous system, early administration of eculizumab, which inhibits the abnormal activation of the complement activation pathway, may be effective.
VL  - 6
IS  - 1
ER  -

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Author Information

Takahiro Yukawa

Department of Trauma and Critical Care Center, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
Takuto Ishida

Department of Trauma and Critical Care Center, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
Toshinobu Yamagishi

Department of Trauma and Critical Care Center, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
Kazuhiro Sugiyama

Department of Trauma and Critical Care Center, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
Yuichi Hamabe

Department of Trauma and Critical Care Center, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan

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Plain Text BibTeX RIS

APA Style

Takahiro Yukawa, Takuto Ishida, Toshinobu Yamagishi, Kazuhiro Sugiyama, Yuichi Hamabe. (2018). Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report. American Journal of Clinical and Experimental Medicine, 6(1), 27-32. https://doi.org/10.11648/j.ajcem.20180601.15

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ACS Style

Takahiro Yukawa; Takuto Ishida; Toshinobu Yamagishi; Kazuhiro Sugiyama; Yuichi Hamabe. Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report. Am. J. Clin. Exp. Med. 2018, 6(1), 27-32. doi: 10.11648/j.ajcem.20180601.15

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AMA Style

Takahiro Yukawa, Takuto Ishida, Toshinobu Yamagishi, Kazuhiro Sugiyama, Yuichi Hamabe. Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report. Am J Clin Exp Med. 2018;6(1):27-32. doi: 10.11648/j.ajcem.20180601.15

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@article{10.11648/j.ajcem.20180601.15,
  author = {Takahiro Yukawa and Takuto Ishida and Toshinobu Yamagishi and Kazuhiro Sugiyama and Yuichi Hamabe},
  title = {Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {6},
  number = {1},
  pages = {27-32},
  doi = {10.11648/j.ajcem.20180601.15},
  url = {https://doi.org/10.11648/j.ajcem.20180601.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20180601.15},
  abstract = {Hemolytic-uremic syndrome (HUS), which is characterized by microvascular hemolytic anemia, consumption thrombocytopenia, and acute renal failure, is a complication of the Shiga-toxin-producing Escherichia coli (STEC) infection. We describe the case of a patient who, despite undergoing plasma exchange and renal replacement therapy for STEC-induced HUS, experienced poor improvement in platelet count, serum creatinine level, and serum lactate dehydrogenase level. The patient developed acute encephalopathy but recovered without permanent organ damage after eculizumab therapy. For severe HUS cases involving the central nervous system, early administration of eculizumab, which inhibits the abnormal activation of the complement activation pathway, may be effective.},
 year = {2018}
}

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TY  - JOUR
T1  - Administration of Eculizumab, a C5 Inhibitor, for the Treatment of Shiga-Toxin-Producing Escherichia coli Infection: A Case Report
AU  - Takahiro Yukawa
AU  - Takuto Ishida
AU  - Toshinobu Yamagishi
AU  - Kazuhiro Sugiyama
AU  - Yuichi Hamabe
Y1  - 2018/03/08
PY  - 2018
N1  - https://doi.org/10.11648/j.ajcem.20180601.15
DO  - 10.11648/j.ajcem.20180601.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 27
EP  - 32
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20180601.15
AB  - Hemolytic-uremic syndrome (HUS), which is characterized by microvascular hemolytic anemia, consumption thrombocytopenia, and acute renal failure, is a complication of the Shiga-toxin-producing Escherichia coli (STEC) infection. We describe the case of a patient who, despite undergoing plasma exchange and renal replacement therapy for STEC-induced HUS, experienced poor improvement in platelet count, serum creatinine level, and serum lactate dehydrogenase level. The patient developed acute encephalopathy but recovered without permanent organ damage after eculizumab therapy. For severe HUS cases involving the central nervous system, early administration of eculizumab, which inhibits the abnormal activation of the complement activation pathway, may be effective.
VL  - 6
IS  - 1
ER  -

Copy | Download