Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors

Yan Ma; Mingming Fang; Xifa Zhou

doi:doi:10.11648/j.ajcem.20170506.18

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Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors

Yan Ma, Mingming Fang, Xifa Zhou

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 6)

Received: 27 December 2017 Published: 29 December 2017

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Abstract

The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 6)
DOI	10.11648/j.ajcem.20170506.18
Page(s)	234-238
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Semaphorin 3B, p53, Malignant Tumor, Tumor Suppression, Mechanism

References

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APA Style

Yan Ma, Mingming Fang, Xifa Zhou. (2017). Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. American Journal of Clinical and Experimental Medicine, 5(6), 234-238. https://doi.org/10.11648/j.ajcem.20170506.18

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ACS Style

Yan Ma; Mingming Fang; Xifa Zhou. Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. Am. J. Clin. Exp. Med. 2017, 5(6), 234-238. doi: 10.11648/j.ajcem.20170506.18

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AMA Style

Yan Ma, Mingming Fang, Xifa Zhou. Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. Am J Clin Exp Med. 2017;5(6):234-238. doi: 10.11648/j.ajcem.20170506.18

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@article{10.11648/j.ajcem.20170506.18,
  author = {Yan Ma and Mingming Fang and Xifa Zhou},
  title = {Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {6},
  pages = {234-238},
  doi = {10.11648/j.ajcem.20170506.18},
  url = {https://doi.org/10.11648/j.ajcem.20170506.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170506.18},
  abstract = {The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.},
 year = {2017}
}

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TY  - JOUR
T1  - Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors
AU  - Yan Ma
AU  - Mingming Fang
AU  - Xifa Zhou
Y1  - 2017/12/29
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170506.18
DO  - 10.11648/j.ajcem.20170506.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 234
EP  - 238
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170506.18
AB  - The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.
VL  - 5
IS  - 6
ER  -

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Author Information

Yan Ma

Department of Radiation Oncology, Changzhou Tumor Hospital, Soochow University, Changzhou, China
Mingming Fang

Department of Radiation Oncology, Changzhou Tumor Hospital, Soochow University, Changzhou, China
Xifa Zhou

Department of Radiation Oncology, Changzhou Tumor Hospital, Soochow University, Changzhou, China

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Plain Text BibTeX RIS

APA Style

Yan Ma, Mingming Fang, Xifa Zhou. (2017). Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. American Journal of Clinical and Experimental Medicine, 5(6), 234-238. https://doi.org/10.11648/j.ajcem.20170506.18

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ACS Style

Yan Ma; Mingming Fang; Xifa Zhou. Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. Am. J. Clin. Exp. Med. 2017, 5(6), 234-238. doi: 10.11648/j.ajcem.20170506.18

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AMA Style

Yan Ma, Mingming Fang, Xifa Zhou. Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. Am J Clin Exp Med. 2017;5(6):234-238. doi: 10.11648/j.ajcem.20170506.18

Copy | Download

@article{10.11648/j.ajcem.20170506.18,
  author = {Yan Ma and Mingming Fang and Xifa Zhou},
  title = {Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {6},
  pages = {234-238},
  doi = {10.11648/j.ajcem.20170506.18},
  url = {https://doi.org/10.11648/j.ajcem.20170506.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170506.18},
  abstract = {The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors
AU  - Yan Ma
AU  - Mingming Fang
AU  - Xifa Zhou
Y1  - 2017/12/29
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170506.18
DO  - 10.11648/j.ajcem.20170506.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 234
EP  - 238
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170506.18
AB  - The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.
VL  - 5
IS  - 6
ER  -

Copy | Download