Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 5, Issue 4) |
| DOI | 10.11648/j.ajcem.20170504.17 |
| Page(s) | 145-150 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Green Tea, White Tea, Rifampin, Chronic Hepatotoxicity
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APA Style
Elham Serki, Mina Hemmati, Alireza Pourtalebi-Firoozabadi. (2017). A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats. American Journal of Clinical and Experimental Medicine, 5(4), 145-150. https://doi.org/10.11648/j.ajcem.20170504.17
ACS Style
Elham Serki; Mina Hemmati; Alireza Pourtalebi-Firoozabadi. A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats. Am. J. Clin. Exp. Med. 2017, 5(4), 145-150. doi: 10.11648/j.ajcem.20170504.17
AMA Style
Elham Serki, Mina Hemmati, Alireza Pourtalebi-Firoozabadi. A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats. Am J Clin Exp Med. 2017;5(4):145-150. doi: 10.11648/j.ajcem.20170504.17
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Download@article{10.11648/j.ajcem.20170504.17,
author = {Elham Serki and Mina Hemmati and Alireza Pourtalebi-Firoozabadi},
title = {A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {5},
number = {4},
pages = {145-150},
doi = {10.11648/j.ajcem.20170504.17},
url = {https://doi.org/10.11648/j.ajcem.20170504.17},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170504.17},
abstract = {Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury.},
year = {2017}
}
TY - JOUR T1 - A Preliminary Study of Comparison of Preventive and Therapeutic Effect of Green and White Tea Against Rifampicin-Induced Chronic Hepatotoxicity in Rats AU - Elham Serki AU - Mina Hemmati AU - Alireza Pourtalebi-Firoozabadi Y1 - 2017/07/17 PY - 2017 N1 - https://doi.org/10.11648/j.ajcem.20170504.17 DO - 10.11648/j.ajcem.20170504.17 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 145 EP - 150 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20170504.17 AB - Many different dietary supplements are currently marked for the management of hepatic illness, but the evidence for effectiveness is mixed. The aim of this study was to evaluate the effect of white and green tea extracts in a rifampicin-induced hepatic damage model of rats. In this study 55 male wistar albino rats were divided into 11 groups of 5 animal, named: normal control, hepatotoxic control with rifampicin (150 mg/kg), hepatotoxic with silymarin, hepatotoxic treated with green tea (250 and 500 mg/kg aqueous extract), hepatotoxic treated with white tea (250 and 500 mg/kg aqueous extract) and preventive groups of green and white tea with mentioned above doses. After 3 weeks treatment with green and white tea, a significant reduction in total cholesterol, triglyceride, LDL cholesterol, malondialdehyde and liver enzymes was observed. In the cases of white tea these changes was notable and dose-dependently improved liver function compared with green tea. The results obtained in this study suggest white tea is much more effective than green tea for prevention and treatment of drug-induced liver injury. VL - 5 IS - 4 ER -
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