Expression of Patched-1 Protein in Aggressive and  Nonaggressive Basal Cell Carcinoma

Putu Marcelina; Alwi Mappiasse; Anis Irawan Anwar; Idham Jaya Ganda; Mohammad Hatta; Rina Masadah

doi:doi:10.11648/j.ajcem.20160405.12

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Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma

Putu Marcelina, Alwi Mappiasse, Anis Irawan Anwar, Idham Jaya Ganda, Mohammad Hatta, Rina Masadah

Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 5)

Received: 30 June 2016 Accepted: 30 July 2016 Published: 21 August 2016

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Abstract

Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biological dysregulation. The aim of this study was to assess the correlation between level of PTCH1 protein expression and aggressiveness of BCC histopathology. This study was an observational and cross-sectional study with analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Hospital Makassar, Hasanuddin University Hospital, Anatomical Pathology Laboratory of Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital, and Sentra Diagnostic Patologia Laboratory, Makassar from September 2014 to January 2016. Total sample was 37 paraffin block evaluated and classified as aggressive and nonaggressive BCC by histopathological finding. Aggressive type BCCs were 34 samples (91.9%) and nonaggressive type were 3 samples (8.1%). Micronodular type was the most common histopathologic feature in 30 of 37 subjects (81.1%) and 30 of 88 histopathological finding (34.1%). Each subject can have more than one histopathologic type. Percentage of strong expression PTCH1 was found highest in pigmented type (33.4%), the percentage of moderate expression PTCH1 was found highest in infiltrating type (60.0%), and the percentage of negative/weak PTCH1 expression was found highest in the nodular type (75.0%). In this study, the correlation between the aggressiveness and PTCH 1 expression was not significant statistically (p>0.05), but it is seen that the frequency of strong PTCH1 expression was found to be higher in aggressive than nonaggressive BCC.

Published in	American Journal of Clinical and Experimental Medicine (Volume 4, Issue 5)
DOI	10.11648/j.ajcem.20160405.12
Page(s)	122-128
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Basal Cell Carcinoma, Patched-1, Aggressive, Nonaggressive

References

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APA Style

Putu Marcelina, Alwi Mappiasse, Anis Irawan Anwar, Idham Jaya Ganda, Mohammad Hatta, et al. (2016). Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma. American Journal of Clinical and Experimental Medicine, 4(5), 122-128. https://doi.org/10.11648/j.ajcem.20160405.12

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ACS Style

Putu Marcelina; Alwi Mappiasse; Anis Irawan Anwar; Idham Jaya Ganda; Mohammad Hatta, et al. Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma. Am. J. Clin. Exp. Med. 2016, 4(5), 122-128. doi: 10.11648/j.ajcem.20160405.12

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AMA Style

Putu Marcelina, Alwi Mappiasse, Anis Irawan Anwar, Idham Jaya Ganda, Mohammad Hatta, et al. Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma. Am J Clin Exp Med. 2016;4(5):122-128. doi: 10.11648/j.ajcem.20160405.12

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@article{10.11648/j.ajcem.20160405.12,
  author = {Putu Marcelina and Alwi Mappiasse and Anis Irawan Anwar and Idham Jaya Ganda and Mohammad Hatta and Rina Masadah},
  title = {Expression of Patched-1 Protein in Aggressive and  Nonaggressive Basal Cell Carcinoma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {5},
  pages = {122-128},
  doi = {10.11648/j.ajcem.20160405.12},
  url = {https://doi.org/10.11648/j.ajcem.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160405.12},
  abstract = {Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biological dysregulation. The aim of this study was to assess the correlation between level of PTCH1 protein expression and aggressiveness of BCC histopathology. This study was an observational and cross-sectional study with analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Hospital Makassar, Hasanuddin University Hospital, Anatomical Pathology Laboratory of Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital, and Sentra Diagnostic Patologia Laboratory, Makassar from September 2014 to January 2016. Total sample was 37 paraffin block evaluated and classified as aggressive and nonaggressive BCC by histopathological finding. Aggressive type BCCs were 34 samples (91.9%) and nonaggressive type were 3 samples (8.1%). Micronodular type was the most common histopathologic feature in 30 of 37 subjects (81.1%) and 30 of 88 histopathological finding (34.1%). Each subject can have more than one histopathologic type. Percentage of strong expression PTCH1 was found highest in pigmented type (33.4%), the percentage of moderate expression PTCH1 was found highest in infiltrating type (60.0%), and the percentage of negative/weak PTCH1 expression was found highest in the nodular type (75.0%). In this study, the correlation between the aggressiveness and PTCH 1 expression was not significant statistically (p>0.05), but it is seen that the frequency of strong PTCH1 expression was found to be higher in aggressive than nonaggressive BCC.},
 year = {2016}
}

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TY  - JOUR
T1  - Expression of Patched-1 Protein in Aggressive and  Nonaggressive Basal Cell Carcinoma
AU  - Putu Marcelina
AU  - Alwi Mappiasse
AU  - Anis Irawan Anwar
AU  - Idham Jaya Ganda
AU  - Mohammad Hatta
AU  - Rina Masadah
Y1  - 2016/08/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ajcem.20160405.12
DO  - 10.11648/j.ajcem.20160405.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 122
EP  - 128
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20160405.12
AB  - Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biological dysregulation. The aim of this study was to assess the correlation between level of PTCH1 protein expression and aggressiveness of BCC histopathology. This study was an observational and cross-sectional study with analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Hospital Makassar, Hasanuddin University Hospital, Anatomical Pathology Laboratory of Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital, and Sentra Diagnostic Patologia Laboratory, Makassar from September 2014 to January 2016. Total sample was 37 paraffin block evaluated and classified as aggressive and nonaggressive BCC by histopathological finding. Aggressive type BCCs were 34 samples (91.9%) and nonaggressive type were 3 samples (8.1%). Micronodular type was the most common histopathologic feature in 30 of 37 subjects (81.1%) and 30 of 88 histopathological finding (34.1%). Each subject can have more than one histopathologic type. Percentage of strong expression PTCH1 was found highest in pigmented type (33.4%), the percentage of moderate expression PTCH1 was found highest in infiltrating type (60.0%), and the percentage of negative/weak PTCH1 expression was found highest in the nodular type (75.0%). In this study, the correlation between the aggressiveness and PTCH 1 expression was not significant statistically (p>0.05), but it is seen that the frequency of strong PTCH1 expression was found to be higher in aggressive than nonaggressive BCC.
VL  - 4
IS  - 5
ER  -

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Author Information

Putu Marcelina

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Alwi Mappiasse

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Anis Irawan Anwar

Department of Dermatology and Venereology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Idham Jaya Ganda

Department of Biostatistic, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Mohammad Hatta

Department of Microbiology, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Rina Masadah

Department of Anatomical Pathology, Medical Faculty, Hasanuddin University, Makassar, Indonesia

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Plain Text BibTeX RIS

APA Style

Putu Marcelina, Alwi Mappiasse, Anis Irawan Anwar, Idham Jaya Ganda, Mohammad Hatta, et al. (2016). Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma. American Journal of Clinical and Experimental Medicine, 4(5), 122-128. https://doi.org/10.11648/j.ajcem.20160405.12

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ACS Style

Putu Marcelina; Alwi Mappiasse; Anis Irawan Anwar; Idham Jaya Ganda; Mohammad Hatta, et al. Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma. Am. J. Clin. Exp. Med. 2016, 4(5), 122-128. doi: 10.11648/j.ajcem.20160405.12

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AMA Style

Putu Marcelina, Alwi Mappiasse, Anis Irawan Anwar, Idham Jaya Ganda, Mohammad Hatta, et al. Expression of Patched-1 Protein in Aggressive and Nonaggressive Basal Cell Carcinoma. Am J Clin Exp Med. 2016;4(5):122-128. doi: 10.11648/j.ajcem.20160405.12

Copy | Download

@article{10.11648/j.ajcem.20160405.12,
  author = {Putu Marcelina and Alwi Mappiasse and Anis Irawan Anwar and Idham Jaya Ganda and Mohammad Hatta and Rina Masadah},
  title = {Expression of Patched-1 Protein in Aggressive and  Nonaggressive Basal Cell Carcinoma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {5},
  pages = {122-128},
  doi = {10.11648/j.ajcem.20160405.12},
  url = {https://doi.org/10.11648/j.ajcem.20160405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160405.12},
  abstract = {Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biological dysregulation. The aim of this study was to assess the correlation between level of PTCH1 protein expression and aggressiveness of BCC histopathology. This study was an observational and cross-sectional study with analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Hospital Makassar, Hasanuddin University Hospital, Anatomical Pathology Laboratory of Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital, and Sentra Diagnostic Patologia Laboratory, Makassar from September 2014 to January 2016. Total sample was 37 paraffin block evaluated and classified as aggressive and nonaggressive BCC by histopathological finding. Aggressive type BCCs were 34 samples (91.9%) and nonaggressive type were 3 samples (8.1%). Micronodular type was the most common histopathologic feature in 30 of 37 subjects (81.1%) and 30 of 88 histopathological finding (34.1%). Each subject can have more than one histopathologic type. Percentage of strong expression PTCH1 was found highest in pigmented type (33.4%), the percentage of moderate expression PTCH1 was found highest in infiltrating type (60.0%), and the percentage of negative/weak PTCH1 expression was found highest in the nodular type (75.0%). In this study, the correlation between the aggressiveness and PTCH 1 expression was not significant statistically (p>0.05), but it is seen that the frequency of strong PTCH1 expression was found to be higher in aggressive than nonaggressive BCC.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Expression of Patched-1 Protein in Aggressive and  Nonaggressive Basal Cell Carcinoma
AU  - Putu Marcelina
AU  - Alwi Mappiasse
AU  - Anis Irawan Anwar
AU  - Idham Jaya Ganda
AU  - Mohammad Hatta
AU  - Rina Masadah
Y1  - 2016/08/21
PY  - 2016
N1  - https://doi.org/10.11648/j.ajcem.20160405.12
DO  - 10.11648/j.ajcem.20160405.12
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 122
EP  - 128
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20160405.12
AB  - Basal cell carcinoma (BCC) or basalioma, is a skin cancer characterized by slow-growing, minimal local invasion, rarely metastasize, but can result in extensive morbidity through local invasion and tissue destruction if the treatment was delayed. In this genomic era, aggressiveness of BCC mainly affected by intrinsic factor such as molecular biological dysregulation. The aim of this study was to assess the correlation between level of PTCH1 protein expression and aggressiveness of BCC histopathology. This study was an observational and cross-sectional study with analytical approach, conducted at Outpatient Clinic of Dermatology and Venereology Department of Dr. Wahidin Sudirohusodo Hospital Makassar, Hasanuddin University Hospital, Anatomical Pathology Laboratory of Dr. Wahidin Sudirohusodo and Hasanuddin University Hospital, and Sentra Diagnostic Patologia Laboratory, Makassar from September 2014 to January 2016. Total sample was 37 paraffin block evaluated and classified as aggressive and nonaggressive BCC by histopathological finding. Aggressive type BCCs were 34 samples (91.9%) and nonaggressive type were 3 samples (8.1%). Micronodular type was the most common histopathologic feature in 30 of 37 subjects (81.1%) and 30 of 88 histopathological finding (34.1%). Each subject can have more than one histopathologic type. Percentage of strong expression PTCH1 was found highest in pigmented type (33.4%), the percentage of moderate expression PTCH1 was found highest in infiltrating type (60.0%), and the percentage of negative/weak PTCH1 expression was found highest in the nodular type (75.0%). In this study, the correlation between the aggressiveness and PTCH 1 expression was not significant statistically (p>0.05), but it is seen that the frequency of strong PTCH1 expression was found to be higher in aggressive than nonaggressive BCC.
VL  - 4
IS  - 5
ER  -

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