Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients

Asrawati Sofyan; Farida Tabri; Sri Vitayani Muchtar; Idham Jayaganda; Gemini Alam; Safruddin Amin; Anis Anwar Irawan

doi:doi:10.11648/j.ajcem.20160405.11

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Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients

Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, Safruddin Amin, Anis Anwar Irawan

Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 5)

Received: 7 June 2015 Accepted: 11 May 2016 Published: 3 August 2016

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Abstract

This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.

Published in	American Journal of Clinical and Experimental Medicine (Volume 4, Issue 5)
DOI	10.11648/j.ajcem.20160405.11
Page(s)	118-121
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Adapalene 0.1% Gel, Clinical Manifestations, Mild Acne Vulgaris, Sebum Levels, Tretinoin 0.05% Gel

References

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[15]	Grosshans, E., Marks R., et al. 1998 Evaluation of clinical efficacy and safety of adapalene 0,1% gel versus tretinoin 0,025% gel in the treatment of acne vulgaris, with particular references to the onset of action and impact on quality of life. Br J Dermatol. 139: 26-33.
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APA Style

Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, et al. (2016). Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. American Journal of Clinical and Experimental Medicine, 4(5), 118-121. https://doi.org/10.11648/j.ajcem.20160405.11

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ACS Style

Asrawati Sofyan; Farida Tabri; Sri Vitayani Muchtar; Idham Jayaganda; Gemini Alam, et al. Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. Am. J. Clin. Exp. Med. 2016, 4(5), 118-121. doi: 10.11648/j.ajcem.20160405.11

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AMA Style

Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, et al. Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. Am J Clin Exp Med. 2016;4(5):118-121. doi: 10.11648/j.ajcem.20160405.11

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@article{10.11648/j.ajcem.20160405.11,
  author = {Asrawati Sofyan and Farida Tabri and Sri Vitayani Muchtar and Idham Jayaganda and Gemini Alam and Safruddin Amin and Anis Anwar Irawan},
  title = {Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {5},
  pages = {118-121},
  doi = {10.11648/j.ajcem.20160405.11},
  url = {https://doi.org/10.11648/j.ajcem.20160405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160405.11},
  abstract = {This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.},
 year = {2016}
}

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TY  - JOUR
T1  - Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients
AU  - Asrawati Sofyan
AU  - Farida Tabri
AU  - Sri Vitayani Muchtar
AU  - Idham Jayaganda
AU  - Gemini Alam
AU  - Safruddin Amin
AU  - Anis Anwar Irawan
Y1  - 2016/08/03
PY  - 2016
N1  - https://doi.org/10.11648/j.ajcem.20160405.11
DO  - 10.11648/j.ajcem.20160405.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 118
EP  - 121
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20160405.11
AB  - This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.
VL  - 4
IS  - 5
ER  -

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Author Information

Asrawati Sofyan

Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Farida Tabri

Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Sri Vitayani Muchtar

Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Idham Jayaganda

Pediatric Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Gemini Alam

Pharmacy Faculty of Hasanuddin University, Makassar, South Sulawesi
Safruddin Amin

Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi
Anis Anwar Irawan

Dermatovenereology Department, Medical Faculty of Hasanuddin University, Makassar, South Sulawesi

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APA Style

Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, et al. (2016). Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. American Journal of Clinical and Experimental Medicine, 4(5), 118-121. https://doi.org/10.11648/j.ajcem.20160405.11

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ACS Style

Asrawati Sofyan; Farida Tabri; Sri Vitayani Muchtar; Idham Jayaganda; Gemini Alam, et al. Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. Am. J. Clin. Exp. Med. 2016, 4(5), 118-121. doi: 10.11648/j.ajcem.20160405.11

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AMA Style

Asrawati Sofyan, Farida Tabri, Sri Vitayani Muchtar, Idham Jayaganda, Gemini Alam, et al. Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients. Am J Clin Exp Med. 2016;4(5):118-121. doi: 10.11648/j.ajcem.20160405.11

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@article{10.11648/j.ajcem.20160405.11,
  author = {Asrawati Sofyan and Farida Tabri and Sri Vitayani Muchtar and Idham Jayaganda and Gemini Alam and Safruddin Amin and Anis Anwar Irawan},
  title = {Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {5},
  pages = {118-121},
  doi = {10.11648/j.ajcem.20160405.11},
  url = {https://doi.org/10.11648/j.ajcem.20160405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160405.11},
  abstract = {This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.},
 year = {2016}
}

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TY  - JOUR
T1  - Comparison of the Effectiveness of Tretinoin 0.05% Gel and Adapalene 0.1% Gel Based on Clinical Manifestations, and Sebum Levels in Mild Acne Vulgaris Patients
AU  - Asrawati Sofyan
AU  - Farida Tabri
AU  - Sri Vitayani Muchtar
AU  - Idham Jayaganda
AU  - Gemini Alam
AU  - Safruddin Amin
AU  - Anis Anwar Irawan
Y1  - 2016/08/03
PY  - 2016
N1  - https://doi.org/10.11648/j.ajcem.20160405.11
DO  - 10.11648/j.ajcem.20160405.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 118
EP  - 121
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20160405.11
AB  - This study aimed to compare the effectiveness of tretinoin 0.05% gel and adapalene 0.1% gel by observing any changes in clinical manifestations and sebum levels before, during and after treatment. This study was carried out in public hospitals and network hospitals in the city of Makassar with double-blind prospective cohort of pre and post treatment. The research sample were thirty-eight patients with mild acne vulgaris who have been observed for the change in the clinical manifestations, measured levels of sebum with sebumeter. The results showed no significant difference between the use of tretinoin 0.05% gel and adapalene 0.1% gel in patients with mild acne vulgaris. There were significant changes of clinical manifestations of two treatment on day 7 and day 14. Levels of sebum by the administration of adapalene 0.1% gel decreased significantly (p <0.05) at day 42, faster than the 0.05% tretinoin gel.
VL  - 4
IS  - 5
ER  -

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