Anti-Inflammatory Effect of <i>Aloe Vera (l) Burm, F.</i> on COX-2 and Histamine Expression in Mice Skin Exposed to UVB

Venyce Laurence Agung; Alwi A. Mappiasse; Siswanto Wahab; Gemini Alam; M. Husni Cangara; Ilhamjaya Patellongi

doi:doi:10.11648/j.ajcem.20160404.11

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Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB

Venyce Laurence Agung, Alwi A. Mappiasse, Siswanto Wahab, Gemini Alam, M. Husni Cangara, Ilhamjaya Patellongi

Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 4)

Received: 20 May 2016 Accepted: 28 May 2016 Published: 13 June 2016

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Abstract

The purpose of this study was to investigate the anti-inflammatory effect of topical aloe vera on COX-2 and histamine expression in mice skin exposed to UVB. COX-2 and histamine expression were examined by using immunochemistry staining in skin samples from totally 20 Swiss Albino mice in the control group, UVB group, UVB+Ethanol group, UVB+Aloe group. The study show topical application of aloe vera with a concentration of 200 mg/kg body weight suppress expression of COX-2 in mice skin exposed to UVB, however it have not been proven to reduce histamine expression. Aloe vera with a dose of 200mg/kg body weight has show anti-inflammatory effects by reduction COX-2 expression that assessed 24 hours after the last treatment.

Published in	American Journal of Clinical and Experimental Medicine (Volume 4, Issue 4)
DOI	10.11648/j.ajcem.20160404.11
Page(s)	94-97
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Aloe Vera, Anti-inflammatory, COX-2, Histamine, UVB

References

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[2]	Degruij, F., Vankranen, H. J., Mullenders, L. H. F. 2001. UV-induced DNA damage, mutations and oncogenic pathways in skin cancer. J Photochem Photobiol, 63, 19-27.
[3]	Baba, T., Hanada, K., Hashimoto, I. 1996. The study of ultraviolet B-induced apoptosis in cultured mouse keratinocytes and in mouse skin. J Dermat Sci., 12, 18-23.
[4]	Haake, A. R., Polakowska, R. R. 1997. Pathways to programmed cell death: Apoptosis and the skin. Curr Opin Dermatol, 4, 247-255.
[5]	Black, A. K., Greaves, M. W., Hensby, C. N., Plummer, N. A. 1980. Increased prostaglandins E2 and F2alpha in human skin at 6 and 24h after ultraviolet B irradiation (290–320 nm). Br J Clin Pharmacol, 5, 431–6.
[6]	Pentland, A. P., Mahoney, M., Jacobs, S. C., Holtzman, M. J. 1990. Enhanced prostaglandin synthesis after ultraviolet injury is mediated by endogenous histamine stimulation. J Clin Invest, 86, 566-574.
[7]	Pentland, A. P. 1998. Arachidonic acid metabolism. In: Freedberg, I. M., Eisen, A. Z., Wolf, K., Austen, K. F., Goldsmith, L. A., Katz, S. I., Fitzpatrick, T. B., (eds.) Fitzpatrick’s Dermatology in General Medicine, 5th edn. New York: McGraw-Hill.
[8]	Muller-Decker, K., Scholz, K., Marks, F., Furstenberger, G. 1995 Diferential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. Mol Carcinogenesis, 12, 31-41.
[9]	Smith, W. L., Garavito, R. M., Dewitt, D. L. 1996. Prostaglandin endoperoxide H synthase (cyclooxygenases-1 and -2). J Biol Chem, 271, 33157-33160.
[10]	Tripp, C. S., Blomme, E. A. G., Chinn, K. S., Hardy, M. M., Lacelle, P. & Pentlandz, A. P. 2003. Epidermal COX-2 Induction Following Ultraviolet Irradiation: Suggested Mechanism for the Role of COX-2 Inhibitionin Photoprotection. J Invest Dermatol, 121, 853-61.
[11]	Klein, L. M., Lavker, R. M., Matis, W. L. & Murphy, G. F. 1989. Degranulation of human mast cells induces an endothelial antigen central toleukocyteadhesion. Proc. Natl. Acad. Sci, 86, 8972-6.
[12]	Sarkar, D., Dutta, A., Das, M., Sarkar, K., Mandal, C. & Chatterjee, M. 2005. Effect of Aloe vera on nitric oxide production by macrophages during inflammation. Indian J Pharmacol 37, 371-5.
[13]	Devaraj, A. & Karpagam, T. 2011. Evaluation on anti-inflammatory activity and analgesic effect of aloe vera leaf extract in rats IRJP, 2, 103-10.
[14]	Williams C. S., Mann M., Dubois R. N. 1999. The Role of Cyclooxygenase in Inflammation, Cancer, and Development. Oncogene, 18, 7908-7916.
[15]	Hamid, A. A. M. A. & Soliman, M. F. 2015. Effect of topical aloe vera on the process of healing of full-thickness skin burn: a histological and immunohistochemical study. Journal of Histology and Histopathology, 2, 1-9.
[16]	Benly, P. 2015. Role of Histamine in Acute Inflammation. Pharm. Sci. and Res. 7(6), 373-376
[17]	Gilchrest, B. A., Soter, N. A., Stoff, J. S., Mihm, M. C. J. R. 1981. The human sunburn reaction: histologic and biochemical studies. J Am Acad Dermatol, 5, 411–22.

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APA Style

Venyce Laurence Agung, Alwi A. Mappiasse, Siswanto Wahab, Gemini Alam, M. Husni Cangara, et al. (2016). Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB. American Journal of Clinical and Experimental Medicine, 4(4), 94-97. https://doi.org/10.11648/j.ajcem.20160404.11

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ACS Style

Venyce Laurence Agung; Alwi A. Mappiasse; Siswanto Wahab; Gemini Alam; M. Husni Cangara, et al. Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB. Am. J. Clin. Exp. Med. 2016, 4(4), 94-97. doi: 10.11648/j.ajcem.20160404.11

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AMA Style

Venyce Laurence Agung, Alwi A. Mappiasse, Siswanto Wahab, Gemini Alam, M. Husni Cangara, et al. Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB. Am J Clin Exp Med. 2016;4(4):94-97. doi: 10.11648/j.ajcem.20160404.11

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@article{10.11648/j.ajcem.20160404.11,
  author = {Venyce Laurence Agung and Alwi A. Mappiasse and Siswanto Wahab and Gemini Alam and M. Husni Cangara and Ilhamjaya Patellongi},
  title = {Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {4},
  pages = {94-97},
  doi = {10.11648/j.ajcem.20160404.11},
  url = {https://doi.org/10.11648/j.ajcem.20160404.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160404.11},
  abstract = {The purpose of this study was to investigate the anti-inflammatory effect of topical aloe vera on COX-2 and histamine expression in mice skin exposed to UVB. COX-2 and histamine expression were examined by using immunochemistry staining in skin samples from totally 20 Swiss Albino mice in the control group, UVB group, UVB+Ethanol group, UVB+Aloe group. The study show topical application of aloe vera with a concentration of 200 mg/kg body weight suppress expression of COX-2 in mice skin exposed to UVB, however it have not been proven to reduce histamine expression. Aloe vera with a dose of 200mg/kg body weight has show anti-inflammatory effects by reduction COX-2 expression that assessed 24 hours after the last treatment.},
 year = {2016}
}

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TY  - JOUR
T1  - Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB
AU  - Venyce Laurence Agung
AU  - Alwi A. Mappiasse
AU  - Siswanto Wahab
AU  - Gemini Alam
AU  - M. Husni Cangara
AU  - Ilhamjaya Patellongi
Y1  - 2016/06/13
PY  - 2016
N1  - https://doi.org/10.11648/j.ajcem.20160404.11
DO  - 10.11648/j.ajcem.20160404.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 94
EP  - 97
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20160404.11
AB  - The purpose of this study was to investigate the anti-inflammatory effect of topical aloe vera on COX-2 and histamine expression in mice skin exposed to UVB. COX-2 and histamine expression were examined by using immunochemistry staining in skin samples from totally 20 Swiss Albino mice in the control group, UVB group, UVB+Ethanol group, UVB+Aloe group. The study show topical application of aloe vera with a concentration of 200 mg/kg body weight suppress expression of COX-2 in mice skin exposed to UVB, however it have not been proven to reduce histamine expression. Aloe vera with a dose of 200mg/kg body weight has show anti-inflammatory effects by reduction COX-2 expression that assessed 24 hours after the last treatment.
VL  - 4
IS  - 4
ER  -

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Author Information

Venyce Laurence Agung

Dermatovenereology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Alwi A. Mappiasse

Dermatovenereology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Siswanto Wahab

Dermatovenereology Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Gemini Alam

Pharmacy Faculty, Hasanuddin University, Makassar, Indonesia
M. Husni Cangara

Pathological and Anatomy Department, Medical Faculty, Hasanuddin University, Makassar, Indonesia
Ilhamjaya Patellongi

Biostatistic, Medical Faculty, Hasanuddin University, Makassar, Indonesia

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APA Style

Venyce Laurence Agung, Alwi A. Mappiasse, Siswanto Wahab, Gemini Alam, M. Husni Cangara, et al. (2016). Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB. American Journal of Clinical and Experimental Medicine, 4(4), 94-97. https://doi.org/10.11648/j.ajcem.20160404.11

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ACS Style

Venyce Laurence Agung; Alwi A. Mappiasse; Siswanto Wahab; Gemini Alam; M. Husni Cangara, et al. Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB. Am. J. Clin. Exp. Med. 2016, 4(4), 94-97. doi: 10.11648/j.ajcem.20160404.11

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AMA Style

Venyce Laurence Agung, Alwi A. Mappiasse, Siswanto Wahab, Gemini Alam, M. Husni Cangara, et al. Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB. Am J Clin Exp Med. 2016;4(4):94-97. doi: 10.11648/j.ajcem.20160404.11

Copy | Download

@article{10.11648/j.ajcem.20160404.11,
  author = {Venyce Laurence Agung and Alwi A. Mappiasse and Siswanto Wahab and Gemini Alam and M. Husni Cangara and Ilhamjaya Patellongi},
  title = {Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {4},
  pages = {94-97},
  doi = {10.11648/j.ajcem.20160404.11},
  url = {https://doi.org/10.11648/j.ajcem.20160404.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160404.11},
  abstract = {The purpose of this study was to investigate the anti-inflammatory effect of topical aloe vera on COX-2 and histamine expression in mice skin exposed to UVB. COX-2 and histamine expression were examined by using immunochemistry staining in skin samples from totally 20 Swiss Albino mice in the control group, UVB group, UVB+Ethanol group, UVB+Aloe group. The study show topical application of aloe vera with a concentration of 200 mg/kg body weight suppress expression of COX-2 in mice skin exposed to UVB, however it have not been proven to reduce histamine expression. Aloe vera with a dose of 200mg/kg body weight has show anti-inflammatory effects by reduction COX-2 expression that assessed 24 hours after the last treatment.},
 year = {2016}
}

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TY  - JOUR
T1  - Anti-Inflammatory Effect of Aloe Vera (l) Burm, F. on COX-2 and Histamine Expression in Mice Skin Exposed to UVB
AU  - Venyce Laurence Agung
AU  - Alwi A. Mappiasse
AU  - Siswanto Wahab
AU  - Gemini Alam
AU  - M. Husni Cangara
AU  - Ilhamjaya Patellongi
Y1  - 2016/06/13
PY  - 2016
N1  - https://doi.org/10.11648/j.ajcem.20160404.11
DO  - 10.11648/j.ajcem.20160404.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 94
EP  - 97
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20160404.11
AB  - The purpose of this study was to investigate the anti-inflammatory effect of topical aloe vera on COX-2 and histamine expression in mice skin exposed to UVB. COX-2 and histamine expression were examined by using immunochemistry staining in skin samples from totally 20 Swiss Albino mice in the control group, UVB group, UVB+Ethanol group, UVB+Aloe group. The study show topical application of aloe vera with a concentration of 200 mg/kg body weight suppress expression of COX-2 in mice skin exposed to UVB, however it have not been proven to reduce histamine expression. Aloe vera with a dose of 200mg/kg body weight has show anti-inflammatory effects by reduction COX-2 expression that assessed 24 hours after the last treatment.
VL  - 4
IS  - 4
ER  -

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