Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection

Jing Zhang; Na Yi; Lidao Bao; Tengfei Yu

doi:doi:10.11648/j.ajcem.20150306.18

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Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection

Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 6)

Received: 24 December 2015 Published: 30 December 2015

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Abstract

To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The C_max, t_max, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.

Published in	American Journal of Clinical and Experimental Medicine (Volume 3, Issue 6)
DOI	10.11648/j.ajcem.20150306.18
Page(s)	368-371
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Ambroxol Hydrochloride, Bioavailability, Pharmacokinetics, HPLC

References

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[3]	Lee HJ, Joung SK, Kim YG, Yoo JY, Han SB (2004) Bioequivalence assessment of ambroxol tablet after a single oral dose administration to healthy male volunteers. Pharmacol Res 49(1): 93-98.
[4]	Ren YC, Wang L, He HB, Tang X (2009) Pulmonary selectivity and local pharmacokinetics of ambroxol hydrochloride dry powder inhalation in rat. J Pharm Sci 98(5): 1797-1803.
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[7]	Rutland BE, Nachreiner RF, Kruger JM (2009) Optimal testing for thyroid hormone concentration after treatment with methimazole in healthy and hyperthyroid cats. J Vet Intern Med 23(5): 1025-1030.
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[10]	Villacampa J, Alcántar F, Rodríguez JM, Morales JM, Herrera J, Rosete R (2003) Pharmacokinetic properties of single-dose loratadine and ambroxol alone and combined in tablet formulations in healthy men. Clin Ther 25(8): 2225-2232.

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APA Style

Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu. (2015). Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. American Journal of Clinical and Experimental Medicine, 3(6), 368-371. https://doi.org/10.11648/j.ajcem.20150306.18

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ACS Style

Jing Zhang; Na Yi; Lidao Bao; Tengfei Yu. Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. Am. J. Clin. Exp. Med. 2015, 3(6), 368-371. doi: 10.11648/j.ajcem.20150306.18

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AMA Style

Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu. Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. Am J Clin Exp Med. 2015;3(6):368-371. doi: 10.11648/j.ajcem.20150306.18

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@article{10.11648/j.ajcem.20150306.18,
  author = {Jing Zhang and Na Yi and Lidao Bao and Tengfei Yu},
  title = {Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {6},
  pages = {368-371},
  doi = {10.11648/j.ajcem.20150306.18},
  url = {https://doi.org/10.11648/j.ajcem.20150306.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150306.18},
  abstract = {To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.},
 year = {2015}
}

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TY  - JOUR
T1  - Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection
AU  - Jing Zhang
AU  - Na Yi
AU  - Lidao Bao
AU  - Tengfei Yu
Y1  - 2015/12/30
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150306.18
DO  - 10.11648/j.ajcem.20150306.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 368
EP  - 371
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150306.18
AB  - To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.
VL  - 3
IS  - 6
ER  -

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Author Information

Jing Zhang

School of Pharmacy, Inner Mongolia Medical University, Hohhot, China
Na Yi

School of Pharmacy, Inner Mongolia Medical University, Hohhot, China
Lidao Bao

School of Pharmacy, Inner Mongolia Medical University, Hohhot, China
Tengfei Yu

School of Pharmacy, Inner Mongolia Medical University, Hohhot, China

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Plain Text BibTeX RIS

APA Style

Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu. (2015). Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. American Journal of Clinical and Experimental Medicine, 3(6), 368-371. https://doi.org/10.11648/j.ajcem.20150306.18

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ACS Style

Jing Zhang; Na Yi; Lidao Bao; Tengfei Yu. Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. Am. J. Clin. Exp. Med. 2015, 3(6), 368-371. doi: 10.11648/j.ajcem.20150306.18

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AMA Style

Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu. Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection. Am J Clin Exp Med. 2015;3(6):368-371. doi: 10.11648/j.ajcem.20150306.18

Copy | Download

@article{10.11648/j.ajcem.20150306.18,
  author = {Jing Zhang and Na Yi and Lidao Bao and Tengfei Yu},
  title = {Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {6},
  pages = {368-371},
  doi = {10.11648/j.ajcem.20150306.18},
  url = {https://doi.org/10.11648/j.ajcem.20150306.18},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150306.18},
  abstract = {To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection
AU  - Jing Zhang
AU  - Na Yi
AU  - Lidao Bao
AU  - Tengfei Yu
Y1  - 2015/12/30
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150306.18
DO  - 10.11648/j.ajcem.20150306.18
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 368
EP  - 371
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150306.18
AB  - To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.
VL  - 3
IS  - 6
ER  -

Copy | Download