Sri Lanka has been recognized as one of the fastest aging populations from the developing countries. There is a large senior population in the country. Since age is the biggest risk factor for Dementia, the need to create awareness and management is an increasing necessity. Sarasvatha Choorna is one of the polyherbal preparation used in Ayurveda for the management of Dementia which consists of 12 medicinal plants. In the present study, an attempt was made to standardize Sarasvatha Choorna by using standard protocols. Standardization was carried out by determination of total ash, water soluble ash, acid insoluble ash, microbial counts, heavy metals, phytochemical screening and development of TLC-densitogram fingerprints. Results revealed that 10.6±0.0% of total ash, 8.4±0.0% of water soluble ash 0.65±0.01% of acid insoluble ash 11.0±0.1% of cold ethanol extractable matter, 13.9±0.1% hot ethanol extractable matter, 13.9±0.1% cold water extractable matter and 20.2±0.2% hot water extractable matter were present in the Sarasvatha Choorna. Pathogenic microorganisms such as Coliforms, Escherichia coli and Salmonella were not found and heavy metal concentrations of Sarasvatha Choorna were well below the recommended upper limits for the tested heavy metals. Phytochemical screening studies revealed the presence of flavonoids, steroid glycosides and coumarins in both water and ethanol extracts of Sarasvatha Choorna. Presence of the raw materials in the Sarasvatha Choorna was confirmed by TLC fingerprints. Present study reveals the quality of Sarasvatha Choorna for the first time and quality control parameters resulted from this study can be used as a reference standard for quality control of Sarasvatha Choorna.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5) |
| DOI | 10.11648/j.ajcem.20150305.26 |
| Page(s) | 288-292 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Sarasvatha Choorna, Dementia, Standardization, Quality Control
| [1] | M. Dissanayaka and S.K.A.P. Health conditions and Health care practices of the aging population in Sri Lanka. Sri Lanka Journal of Population Studies. 2011. Vol, 12-13, p 55. |
| [2] | P. Kumar and M. Clark. Clinical Medicine. 4th edition. 1998, p1114. |
| [3] | Bhvaprakasha of Bhavamisra, Trancelated by Bulusu Sitharam, Chawkamba Oriantalia, Varanasi, 2011, Vol 2, Chapter 22, p 225. |
| [4] | N.V. Kokare, K.A. Wadkar and M.S. Review on standardization of Herbal Churna. International Journal and Research Ayurveda Pharmacy. 2014, 5, 397-401. |
| [5] | WHO. General Guidelines for Methodologies on Research and Evaluation of Traditional Medicine, World Health Organization, Geneva. 2000. |
| [6] | Sri Lanka standard. Publication of Sri Lanka Standards Institution, Sri Lanka. 516/1, Section 1: 2013. |
| [7] | Sri Lanka standard. Publication of Sri Lanka Standards Institution, Sri Lanka. 516/2, Section 2: 1991. |
| [8] | Sri Lanka standard. Publication of Sri Lanka Standards Institution, Sri Lanka. 516/3, Section 1: 2013. |
| [9] | Sri Lanka standard. Publication of Sri Lanka Standards Institution, Sri Lanka. 516/12: 2013. |
| [10] | Sri Lanka standard. Publication of Sri Lanka Standards Institution, Sri Lanka. 516/5: 2013. |
| [11] | Sri Lanka standard. Publication of Sri Lanka Standards Institution, Sri Lanka. 516/6: 1992. |
| [12] | Official Methods of Analysis of AOAC International. AOAC International. Garthersburg MD, USA, Official Methods 2012; 975.03. |
| [13] | Official Methods of Analysis of AOAC International. AOAC International. Garthersburg MD, USA, Official Methods 2012; 999.10. |
| [14] | Official Methods of Analysis of AOAC International. AOAC International. Garthersburg MD, USA, Official Methods 2012; 986.15. |
| [15] | R.N.S. Yadav and M. Agarwala. Phytochemical analysis of some medicinal plants. Journal of Phytology. 2011; 3: 10-14. |
| [16] | N.R. Ekka, K.P. Namdeo and P.K. Samal. Standardization strategies for herbal drugs – An overview. Research Journal of Pharmacy and Technology. 2008, 1: 310-312. |
| [17] | A. Maruthupandian and V.R. Mohan. GC-MS analysis of ethanol extract of Wattakaka volubilis (l.f.) Stapf. Leaf. International Journal of Phytomedicine. 2011, 3: 59-62. |
| [18] | R.K.N. Trimurthulu and G. Reddy. Medicinal plants used by people of Medak district Andhra Pradesh. Indian Journal of Traditional Knowledge, 2010, 9: 184-190. |
APA Style
T. D. N. Karunaratne, Kahapola Sugataratana, H. A. S. Ariyawansa, H. A. de Silva, K. Samarasingha, et al. (2015). Standardization of Sarasvatha Choorna: Used as a Remedy for Dementia. American Journal of Clinical and Experimental Medicine, 3(5), 288-292. https://doi.org/10.11648/j.ajcem.20150305.26
ACS Style
T. D. N. Karunaratne; Kahapola Sugataratana; H. A. S. Ariyawansa; H. A. de Silva; K. Samarasingha, et al. Standardization of Sarasvatha Choorna: Used as a Remedy for Dementia. Am. J. Clin. Exp. Med. 2015, 3(5), 288-292. doi: 10.11648/j.ajcem.20150305.26
AMA Style
T. D. N. Karunaratne, Kahapola Sugataratana, H. A. S. Ariyawansa, H. A. de Silva, K. Samarasingha, et al. Standardization of Sarasvatha Choorna: Used as a Remedy for Dementia. Am J Clin Exp Med. 2015;3(5):288-292. doi: 10.11648/j.ajcem.20150305.26
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Download@article{10.11648/j.ajcem.20150305.26,
author = {T. D. N. Karunaratne and Kahapola Sugataratana and H. A. S. Ariyawansa and H. A. de Silva and K. Samarasingha and L. D. A. M. Arawwawala},
title = {Standardization of Sarasvatha Choorna: Used as a Remedy for Dementia},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {3},
number = {5},
pages = {288-292},
doi = {10.11648/j.ajcem.20150305.26},
url = {https://doi.org/10.11648/j.ajcem.20150305.26},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150305.26},
abstract = {Sri Lanka has been recognized as one of the fastest aging populations from the developing countries. There is a large senior population in the country. Since age is the biggest risk factor for Dementia, the need to create awareness and management is an increasing necessity. Sarasvatha Choorna is one of the polyherbal preparation used in Ayurveda for the management of Dementia which consists of 12 medicinal plants. In the present study, an attempt was made to standardize Sarasvatha Choorna by using standard protocols. Standardization was carried out by determination of total ash, water soluble ash, acid insoluble ash, microbial counts, heavy metals, phytochemical screening and development of TLC-densitogram fingerprints. Results revealed that 10.6±0.0% of total ash, 8.4±0.0% of water soluble ash 0.65±0.01% of acid insoluble ash 11.0±0.1% of cold ethanol extractable matter, 13.9±0.1% hot ethanol extractable matter, 13.9±0.1% cold water extractable matter and 20.2±0.2% hot water extractable matter were present in the Sarasvatha Choorna. Pathogenic microorganisms such as Coliforms, Escherichia coli and Salmonella were not found and heavy metal concentrations of Sarasvatha Choorna were well below the recommended upper limits for the tested heavy metals. Phytochemical screening studies revealed the presence of flavonoids, steroid glycosides and coumarins in both water and ethanol extracts of Sarasvatha Choorna. Presence of the raw materials in the Sarasvatha Choorna was confirmed by TLC fingerprints. Present study reveals the quality of Sarasvatha Choorna for the first time and quality control parameters resulted from this study can be used as a reference standard for quality control of Sarasvatha Choorna.},
year = {2015}
}
TY - JOUR T1 - Standardization of Sarasvatha Choorna: Used as a Remedy for Dementia AU - T. D. N. Karunaratne AU - Kahapola Sugataratana AU - H. A. S. Ariyawansa AU - H. A. de Silva AU - K. Samarasingha AU - L. D. A. M. Arawwawala Y1 - 2015/11/26 PY - 2015 N1 - https://doi.org/10.11648/j.ajcem.20150305.26 DO - 10.11648/j.ajcem.20150305.26 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 288 EP - 292 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20150305.26 AB - Sri Lanka has been recognized as one of the fastest aging populations from the developing countries. There is a large senior population in the country. Since age is the biggest risk factor for Dementia, the need to create awareness and management is an increasing necessity. Sarasvatha Choorna is one of the polyherbal preparation used in Ayurveda for the management of Dementia which consists of 12 medicinal plants. In the present study, an attempt was made to standardize Sarasvatha Choorna by using standard protocols. Standardization was carried out by determination of total ash, water soluble ash, acid insoluble ash, microbial counts, heavy metals, phytochemical screening and development of TLC-densitogram fingerprints. Results revealed that 10.6±0.0% of total ash, 8.4±0.0% of water soluble ash 0.65±0.01% of acid insoluble ash 11.0±0.1% of cold ethanol extractable matter, 13.9±0.1% hot ethanol extractable matter, 13.9±0.1% cold water extractable matter and 20.2±0.2% hot water extractable matter were present in the Sarasvatha Choorna. Pathogenic microorganisms such as Coliforms, Escherichia coli and Salmonella were not found and heavy metal concentrations of Sarasvatha Choorna were well below the recommended upper limits for the tested heavy metals. Phytochemical screening studies revealed the presence of flavonoids, steroid glycosides and coumarins in both water and ethanol extracts of Sarasvatha Choorna. Presence of the raw materials in the Sarasvatha Choorna was confirmed by TLC fingerprints. Present study reveals the quality of Sarasvatha Choorna for the first time and quality control parameters resulted from this study can be used as a reference standard for quality control of Sarasvatha Choorna. VL - 3 IS - 5 ER -
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