Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh

Mohammad Mofizul Islam; Shahana Akhter Rahman; Mohammad Imnul Islam; Satya Narayan Chaudhary; Mohammad Aminul Islam; Mohammed Mahbubul Islam; Manik Kuma Talukder

doi:doi:10.11648/j.ajcem.20150305.20

Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh

Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, Mohammed Mahbubul Islam, Manik Kuma Talukder

Published in American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5)

Received: 29 September 2015 Accepted: 15 October 2015 Published: 30 October 2015

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Abstract

Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.

Published in	American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5)
DOI	10.11648/j.ajcem.20150305.20
Page(s)	255-259
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Lipid Profile, Systemic Lupus Erythematosus Disease Activity Index, Dose of Steroid

References

[1]	Ardoin SP, Schanberg LE. Systemic Lupus Erythematosus. In: Kliegman RM, Stanton BF, St.Game JW, Schor NF, Behrman RE, editors. Nelson Textbook of pediatrics. 19th edition. Philadelphia: Elsevier Saunders; 2012. P. 841-46.
[2]	Silverman E, Eddy A. Systemic Lupus Erythematosus. In: Cassidy JT, Petty RE, Laxer RM, Lindsley CB, editors. Textbook of Paediatric Rheumatology. 6th edition. Philadelphia: Sunders; 2011. P. 315-43
[3]	Kakati S, Doley B, Devee A, Dihingia P, Sarma PK. Serum lipid profiles in patients with systemic lupus erythematosus. J Indian Rheumatol Assoc 2003; 11: 5-7.
[4]	Toms TE, Panoulas VF, Kitas GD. Dyslipidaemia in Rheumatological Autoimmune Diseases. Open Cardiovasc Med J 2011; 5: 64-75.
[5]	Sarkissian T, Beyenne J, Feldman B, Adeli K, Silverman E. The complex nature of the interaction between disease activity and therapy on the lipid profile in patients with pediatric systemic lupus erythematosus. Arthritis & Rheumatism 2006; 54:1283-90.
[6]	Sarkissian T, Beyene J, Feldman B, McCrindle B, Silverman ED. Longitudinal examination of lipid profiles in pediatric systemic lupus erythematosus. Arthritis & Rheum 2007; 56: 613-38.
[7]	Thorbinson C, Watson L, Roberts C, Beresford MW, PReS-FINAL-2290: Is an Abnormal Lipid Profile at Diagnosis Related to Increased Disease Activity in JSLE Patients (Poster Presentation). Pediatric Rheumatology 2013; 11 (Suppl2): P 280
[8]	Liang MH, Mandl LA, Costenbader K, Fox E, Karlson E. Atherosclerotic Vascular Disease in Systemic Lupus Erythematosus. J Natl Med Assoc 2002; 94: 813-19.
[9]	Svenungsson E, Jensen-Urstad K, Heimburger M, Silveira A, Hamsten A, Witztum, JL et al. Risk Factor for Cardiovascular Disease in Systemic Lupus Erythematosus. Circulation 2001; 104: 1887-93.
[10]	Lipid abnormalities in Children with Systemic Lupus Erythematosus. AAP Grand Rounds 2006; 16; 45. http://aapgrounds.aapublications.org/content/16/4/45.
[11]	Ilowite NT, Samuel P, Ginzler E, Jacobson MS. Dyslipoproteinemia in pediatric systemic lupus erythematosus. Arthritis Rheum 2008; 31: 859-63.
[12]	Brunner HI, Huggings J, Klein-Gitelman MS. Pediatric SLE-towards a comprehensive management plan. Nat. Rev. Rheumatol 2011; 7: 225-33.
[13]	Ettinger WH, Goldberg AP, Applebaum-Bowden D, Hazzard WR. Dyslipoproteinemia in systemic lupus erythematosus: effect of corticosteroids. Am J Med 1987; 83: 503-8.
[14]	Siripaitoon B, Osiri M, Vongthavaravat V, Akkasilpa S, Deesomchok U. The prevalence of dyslipoproteinemia in Thai patients with systemic lupus erythematosus. Lupus 2004; 13: 961-8.
[15]	Ettinger WH jr, Hazzard WR. Prednisone increases very low density lipoprotein and high density lipoprotein in healthy men. Metabolism 1988; 37: 1055-8.
[16]	Liang K, Vaziri ND. Down-regulation of hepatic lipase expression in experimental nephrotic syndrome. Kidney Int 1997; 51: 1933-7.
[17]	Vaziri ND, Liang K, Parks JS. Down-regulation of hepatic lecithin:cholesterol acyltransferase gene expression in chronic renal failure. Kidney International 2001; 59: 2192- 96.
[18]	Tyrrell PN, Beyene J, Benseler SM, Sarkissian T, Silverman ED. Predictors of lipid abnormalities in children with new-onset systemic lupus erythematosus. J Rheumatol 2007; 34: 2112-9.

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APA Style

Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, et al. (2015). Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. American Journal of Clinical and Experimental Medicine, 3(5), 255-259. https://doi.org/10.11648/j.ajcem.20150305.20

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ACS Style

Mohammad Mofizul Islam; Shahana Akhter Rahman; Mohammad Imnul Islam; Satya Narayan Chaudhary; Mohammad Aminul Islam, et al. Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am. J. Clin. Exp. Med. 2015, 3(5), 255-259. doi: 10.11648/j.ajcem.20150305.20

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AMA Style

Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, et al. Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am J Clin Exp Med. 2015;3(5):255-259. doi: 10.11648/j.ajcem.20150305.20

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@article{10.11648/j.ajcem.20150305.20,
  author = {Mohammad Mofizul Islam and Shahana Akhter Rahman and Mohammad Imnul Islam and Satya Narayan Chaudhary and Mohammad Aminul Islam and Mohammed Mahbubul Islam and Manik Kuma Talukder},
  title = {Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {5},
  pages = {255-259},
  doi = {10.11648/j.ajcem.20150305.20},
  url = {https://doi.org/10.11648/j.ajcem.20150305.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150305.20},
  abstract = {Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.},
 year = {2015}
}

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TY  - JOUR
T1  - Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh
AU  - Mohammad Mofizul Islam
AU  - Shahana Akhter Rahman
AU  - Mohammad Imnul Islam
AU  - Satya Narayan Chaudhary
AU  - Mohammad Aminul Islam
AU  - Mohammed Mahbubul Islam
AU  - Manik Kuma Talukder
Y1  - 2015/10/30
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150305.20
DO  - 10.11648/j.ajcem.20150305.20
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 255
EP  - 259
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150305.20
AB  - Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.
VL  - 3
IS  - 5
ER  -

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Author Information

Mohammad Mofizul Islam

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Shahana Akhter Rahman

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammad Imnul Islam

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Satya Narayan Chaudhary

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammad Aminul Islam

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mohammed Mahbubul Islam

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Manik Kuma Talukder

Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

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APA Style

Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, et al. (2015). Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. American Journal of Clinical and Experimental Medicine, 3(5), 255-259. https://doi.org/10.11648/j.ajcem.20150305.20

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ACS Style

Mohammad Mofizul Islam; Shahana Akhter Rahman; Mohammad Imnul Islam; Satya Narayan Chaudhary; Mohammad Aminul Islam, et al. Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am. J. Clin. Exp. Med. 2015, 3(5), 255-259. doi: 10.11648/j.ajcem.20150305.20

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AMA Style

Mohammad Mofizul Islam, Shahana Akhter Rahman, Mohammad Imnul Islam, Satya Narayan Chaudhary, Mohammad Aminul Islam, et al. Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh. Am J Clin Exp Med. 2015;3(5):255-259. doi: 10.11648/j.ajcem.20150305.20

Copy | Download

@article{10.11648/j.ajcem.20150305.20,
  author = {Mohammad Mofizul Islam and Shahana Akhter Rahman and Mohammad Imnul Islam and Satya Narayan Chaudhary and Mohammad Aminul Islam and Mohammed Mahbubul Islam and Manik Kuma Talukder},
  title = {Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {3},
  number = {5},
  pages = {255-259},
  doi = {10.11648/j.ajcem.20150305.20},
  url = {https://doi.org/10.11648/j.ajcem.20150305.20},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150305.20},
  abstract = {Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.},
 year = {2015}
}

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TY  - JOUR
T1  - Serum Lipid Profiles in Pediatric Systemic Lupus Erythematosus Patients: A Study from Bangladesh
AU  - Mohammad Mofizul Islam
AU  - Shahana Akhter Rahman
AU  - Mohammad Imnul Islam
AU  - Satya Narayan Chaudhary
AU  - Mohammad Aminul Islam
AU  - Mohammed Mahbubul Islam
AU  - Manik Kuma Talukder
Y1  - 2015/10/30
PY  - 2015
N1  - https://doi.org/10.11648/j.ajcem.20150305.20
DO  - 10.11648/j.ajcem.20150305.20
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 255
EP  - 259
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20150305.20
AB  - Aim: To assess the lipid profile in pediatric SLE (pSLE) patients in active disease state and compare it with inactive state. Methodology: It was an observational study carried out in the Department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka-1000, Bangladesh from January 2013 to June 2014. A total 30 patients fulfilling the ACR 1997 criteria were enrolled in this study. Age and sex matched 15 controls were also included. Lipid profiles were measured at diagnosis, at 3 months follow up and at 9 months follow up. Results: At the time of diagnosis, pSLE patients’ mean triglyceride level and HDL cholesterol levels were significantly abnormal. At 3 three months follow up, when disease activity was high and patients were on high dose steroid therapy, there was increased total, LDL and HDL cholesterol level. At 9 months follow up when most of the patients had inactive disease and were on low dose steroid, all the lipids were within normal range. Comparison of active disease group with inactive disease group at 9 months found significant improvement of total cholesterol, triglycerides and HDL cholesterol levels. Conclusion: Control of SLE seems to be the most important factor in normalizing the lipids.
VL  - 3
IS  - 5
ER  -

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