This comparative study was performed for the evaluation of the thrombolytic and anti-arthritic effects of methanolic leaf extracts of P. acerifolium and S. caseolaris. The thrombolytic activity was evaluated by using the in vitro clot lysis model and anti-denaturation method was performed by using bovine serum albumin (BSA) to evaluate the anti-arthritic potential. Here, the thrombolytic activity of P. acerifolium leaves showed (35.15 ± 1.77)% whereas S. caseolaris leaves exhibited (26.05 ± 0.92)% and standard streptokinase demonstrated (63.54 ± 2.61)%. In the case of anti-arthritic study, P. acerifolium showed (35.48 ± 0.98)% at lower concentration and (76.64 ± 1.29)% at higher concentration and ,S. caseolaris exhibited (27.42 ± 0.98)% and (59.68 ± 1.07)% at lower and higher concentration respectively whereas standard diclofenac sodium showed (52.31 ± 0.56)% at 31.25 µg/ml and (86.67 ± 0.92)% at 1000 µg/ml. The results of these experiments suggest that methanolic leaf extract of P. acerifolium showed higher thrombolytic and anti-arthritic activities than S. caseolaris.
| Published in | American Journal of Clinical and Experimental Medicine (Volume 3, Issue 5) |
| DOI | 10.11648/j.ajcem.20150305.15 |
| Page(s) | 228-232 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
P. acerifolium, S. caseolaris, Thrombolytic, Streptokinase, Anti-arthritic, Protein Denaturation
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APA Style
Sudipta Chowdhury, Md. Irfan Amin Chowdury, Mohammad Nazmul Alam, Abu Hena Mustafa Kamal, S. M. Arif Bin Alam, et al. (2015). Comparative Study of Potential Thrombolytic and Anti-arthritic Activities of Pterospermum acerifolium and Sonneratia caseolaris Leaves. American Journal of Clinical and Experimental Medicine, 3(5), 228-232. https://doi.org/10.11648/j.ajcem.20150305.15
ACS Style
Sudipta Chowdhury; Md. Irfan Amin Chowdury; Mohammad Nazmul Alam; Abu Hena Mustafa Kamal; S. M. Arif Bin Alam, et al. Comparative Study of Potential Thrombolytic and Anti-arthritic Activities of Pterospermum acerifolium and Sonneratia caseolaris Leaves. Am. J. Clin. Exp. Med. 2015, 3(5), 228-232. doi: 10.11648/j.ajcem.20150305.15
AMA Style
Sudipta Chowdhury, Md. Irfan Amin Chowdury, Mohammad Nazmul Alam, Abu Hena Mustafa Kamal, S. M. Arif Bin Alam, et al. Comparative Study of Potential Thrombolytic and Anti-arthritic Activities of Pterospermum acerifolium and Sonneratia caseolaris Leaves. Am J Clin Exp Med. 2015;3(5):228-232. doi: 10.11648/j.ajcem.20150305.15
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Download@article{10.11648/j.ajcem.20150305.15,
author = {Sudipta Chowdhury and Md. Irfan Amin Chowdury and Mohammad Nazmul Alam and Abu Hena Mustafa Kamal and S. M. Arif Bin Alam and Sharmin Sultana and Tamanna Jahan},
title = {Comparative Study of Potential Thrombolytic and Anti-arthritic Activities of Pterospermum acerifolium and Sonneratia caseolaris Leaves},
journal = {American Journal of Clinical and Experimental Medicine},
volume = {3},
number = {5},
pages = {228-232},
doi = {10.11648/j.ajcem.20150305.15},
url = {https://doi.org/10.11648/j.ajcem.20150305.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20150305.15},
abstract = {This comparative study was performed for the evaluation of the thrombolytic and anti-arthritic effects of methanolic leaf extracts of P. acerifolium and S. caseolaris. The thrombolytic activity was evaluated by using the in vitro clot lysis model and anti-denaturation method was performed by using bovine serum albumin (BSA) to evaluate the anti-arthritic potential. Here, the thrombolytic activity of P. acerifolium leaves showed (35.15 ± 1.77)% whereas S. caseolaris leaves exhibited (26.05 ± 0.92)% and standard streptokinase demonstrated (63.54 ± 2.61)%. In the case of anti-arthritic study, P. acerifolium showed (35.48 ± 0.98)% at lower concentration and (76.64 ± 1.29)% at higher concentration and ,S. caseolaris exhibited (27.42 ± 0.98)% and (59.68 ± 1.07)% at lower and higher concentration respectively whereas standard diclofenac sodium showed (52.31 ± 0.56)% at 31.25 µg/ml and (86.67 ± 0.92)% at 1000 µg/ml. The results of these experiments suggest that methanolic leaf extract of P. acerifolium showed higher thrombolytic and anti-arthritic activities than S. caseolaris.},
year = {2015}
}
TY - JOUR T1 - Comparative Study of Potential Thrombolytic and Anti-arthritic Activities of Pterospermum acerifolium and Sonneratia caseolaris Leaves AU - Sudipta Chowdhury AU - Md. Irfan Amin Chowdury AU - Mohammad Nazmul Alam AU - Abu Hena Mustafa Kamal AU - S. M. Arif Bin Alam AU - Sharmin Sultana AU - Tamanna Jahan Y1 - 2015/10/08 PY - 2015 N1 - https://doi.org/10.11648/j.ajcem.20150305.15 DO - 10.11648/j.ajcem.20150305.15 T2 - American Journal of Clinical and Experimental Medicine JF - American Journal of Clinical and Experimental Medicine JO - American Journal of Clinical and Experimental Medicine SP - 228 EP - 232 PB - Science Publishing Group SN - 2330-8133 UR - https://doi.org/10.11648/j.ajcem.20150305.15 AB - This comparative study was performed for the evaluation of the thrombolytic and anti-arthritic effects of methanolic leaf extracts of P. acerifolium and S. caseolaris. The thrombolytic activity was evaluated by using the in vitro clot lysis model and anti-denaturation method was performed by using bovine serum albumin (BSA) to evaluate the anti-arthritic potential. Here, the thrombolytic activity of P. acerifolium leaves showed (35.15 ± 1.77)% whereas S. caseolaris leaves exhibited (26.05 ± 0.92)% and standard streptokinase demonstrated (63.54 ± 2.61)%. In the case of anti-arthritic study, P. acerifolium showed (35.48 ± 0.98)% at lower concentration and (76.64 ± 1.29)% at higher concentration and ,S. caseolaris exhibited (27.42 ± 0.98)% and (59.68 ± 1.07)% at lower and higher concentration respectively whereas standard diclofenac sodium showed (52.31 ± 0.56)% at 31.25 µg/ml and (86.67 ± 0.92)% at 1000 µg/ml. The results of these experiments suggest that methanolic leaf extract of P. acerifolium showed higher thrombolytic and anti-arthritic activities than S. caseolaris. VL - 3 IS - 5 ER -
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