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Serum Transthyretin Profile in Patients with Chronic Renal Failure on Hemodialysis at Souro Sanou University Hospital in Bobo-Dioulasso

Received: 13 September 2023     Accepted: 7 October 2023     Published: 31 October 2023
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Abstract

Introduction: Transthyretin (prealbumin) is a protein secreted by the liver that is involved in the assessment of undernutrition and nutritional intake. Undernutrition in hemodialysis patients is associated with a worsening of vital prognosis. The main objective of this study was to investigate the transthyretin profile in hemodialysis patients with chronic kidney disease (CKD) in the absence of inflammation in Bobo-Dioulasso, Burkina Faso. Material and methods: This was a prospective study of CKD hemodialysis patients recruited at the CHU-SS from 1er January 2022 to 28 February 2022. Socio-demographic data were obtained after examination of the medical records of hemodialysis CKD patients. All biochemical parameters were measured on the COBAS® 6000 automated system. Colorimetric methods were used to measure urea (urease/Glutamate dehydrogenase), creatinine (modified Jaffé) and albumin (bromocresol green). CRP, alpha-1-glucoprotein acid and transthyretin were determined by the immunoturbidimetric method. Results and discussion: A total of 41 hemodialysis patients were included in the study. The mean age was 42.93±12.21 years with extremes ranging from 22 to 72 years. There was a male predominance with a sex ratio (M/F) of 1.56. The mean BMI of the patients was 20.70±2.87 kg/m2 with extremes from 14.45 to 28.28 kg/m2. Mean transthyretin was 0.47±0.13 g/L. Significant positive correlations were observed with albumin (r=0.77; p=0.0000) and alpha 1 glycoprotein acid (r=0.43; p= 0.004). In the absence of inflammation in the patient group, only one patient (2.44%) presented with hypotranthyretinemia. Conclusion: Transthyretin provides quantitative and clinically useful data for better management of undernutrition and, above all, for predicting the morbidity and mortality associated with protein-energy undernutrition.

Published in Advances in Biochemistry (Volume 11, Issue 4)
DOI 10.11648/j.ab.20231104.11
Page(s) 47-52
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Assessment of Undernutrition, Prealbumin, Albumin, Chronic Renal Failure, Dialysis

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    Arnaud Kouraogo, Ollo Da, Aoua Semdé, Alice Kiba, Fabienne Soudre, et al. (2023). Serum Transthyretin Profile in Patients with Chronic Renal Failure on Hemodialysis at Souro Sanou University Hospital in Bobo-Dioulasso. Advances in Biochemistry, 11(4), 47-52. https://doi.org/10.11648/j.ab.20231104.11

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    Arnaud Kouraogo; Ollo Da; Aoua Semdé; Alice Kiba; Fabienne Soudre, et al. Serum Transthyretin Profile in Patients with Chronic Renal Failure on Hemodialysis at Souro Sanou University Hospital in Bobo-Dioulasso. Adv. Biochem. 2023, 11(4), 47-52. doi: 10.11648/j.ab.20231104.11

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    AMA Style

    Arnaud Kouraogo, Ollo Da, Aoua Semdé, Alice Kiba, Fabienne Soudre, et al. Serum Transthyretin Profile in Patients with Chronic Renal Failure on Hemodialysis at Souro Sanou University Hospital in Bobo-Dioulasso. Adv Biochem. 2023;11(4):47-52. doi: 10.11648/j.ab.20231104.11

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  • @article{10.11648/j.ab.20231104.11,
      author = {Arnaud Kouraogo and Ollo Da and Aoua Semdé and Alice Kiba and Fabienne Soudre and Raoul Karfo and Amidou Sawadogo and Emmanuel Zongo and Fatou Gueye Tall and Abdoul Salam Ouédraogo and Sanata Bamba and Georges Anicet Ouédraogo and Elie Kabre and Jean Sakande},
      title = {Serum Transthyretin Profile in Patients with Chronic Renal Failure on Hemodialysis at Souro Sanou University Hospital in Bobo-Dioulasso},
      journal = {Advances in Biochemistry},
      volume = {11},
      number = {4},
      pages = {47-52},
      doi = {10.11648/j.ab.20231104.11},
      url = {https://doi.org/10.11648/j.ab.20231104.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20231104.11},
      abstract = {Introduction: Transthyretin (prealbumin) is a protein secreted by the liver that is involved in the assessment of undernutrition and nutritional intake. Undernutrition in hemodialysis patients is associated with a worsening of vital prognosis. The main objective of this study was to investigate the transthyretin profile in hemodialysis patients with chronic kidney disease (CKD) in the absence of inflammation in Bobo-Dioulasso, Burkina Faso. Material and methods: This was a prospective study of CKD hemodialysis patients recruited at the CHU-SS from 1er January 2022 to 28 February 2022. Socio-demographic data were obtained after examination of the medical records of hemodialysis CKD patients. All biochemical parameters were measured on the COBAS® 6000 automated system. Colorimetric methods were used to measure urea (urease/Glutamate dehydrogenase), creatinine (modified Jaffé) and albumin (bromocresol green). CRP, alpha-1-glucoprotein acid and transthyretin were determined by the immunoturbidimetric method. Results and discussion: A total of 41 hemodialysis patients were included in the study. The mean age was 42.93±12.21 years with extremes ranging from 22 to 72 years. There was a male predominance with a sex ratio (M/F) of 1.56. The mean BMI of the patients was 20.70±2.87 kg/m2 with extremes from 14.45 to 28.28 kg/m2. Mean transthyretin was 0.47±0.13 g/L. Significant positive correlations were observed with albumin (r=0.77; p=0.0000) and alpha 1 glycoprotein acid (r=0.43; p= 0.004). In the absence of inflammation in the patient group, only one patient (2.44%) presented with hypotranthyretinemia. Conclusion: Transthyretin provides quantitative and clinically useful data for better management of undernutrition and, above all, for predicting the morbidity and mortality associated with protein-energy undernutrition.
    },
     year = {2023}
    }
    

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  • TY  - JOUR
    T1  - Serum Transthyretin Profile in Patients with Chronic Renal Failure on Hemodialysis at Souro Sanou University Hospital in Bobo-Dioulasso
    AU  - Arnaud Kouraogo
    AU  - Ollo Da
    AU  - Aoua Semdé
    AU  - Alice Kiba
    AU  - Fabienne Soudre
    AU  - Raoul Karfo
    AU  - Amidou Sawadogo
    AU  - Emmanuel Zongo
    AU  - Fatou Gueye Tall
    AU  - Abdoul Salam Ouédraogo
    AU  - Sanata Bamba
    AU  - Georges Anicet Ouédraogo
    AU  - Elie Kabre
    AU  - Jean Sakande
    Y1  - 2023/10/31
    PY  - 2023
    N1  - https://doi.org/10.11648/j.ab.20231104.11
    DO  - 10.11648/j.ab.20231104.11
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 47
    EP  - 52
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20231104.11
    AB  - Introduction: Transthyretin (prealbumin) is a protein secreted by the liver that is involved in the assessment of undernutrition and nutritional intake. Undernutrition in hemodialysis patients is associated with a worsening of vital prognosis. The main objective of this study was to investigate the transthyretin profile in hemodialysis patients with chronic kidney disease (CKD) in the absence of inflammation in Bobo-Dioulasso, Burkina Faso. Material and methods: This was a prospective study of CKD hemodialysis patients recruited at the CHU-SS from 1er January 2022 to 28 February 2022. Socio-demographic data were obtained after examination of the medical records of hemodialysis CKD patients. All biochemical parameters were measured on the COBAS® 6000 automated system. Colorimetric methods were used to measure urea (urease/Glutamate dehydrogenase), creatinine (modified Jaffé) and albumin (bromocresol green). CRP, alpha-1-glucoprotein acid and transthyretin were determined by the immunoturbidimetric method. Results and discussion: A total of 41 hemodialysis patients were included in the study. The mean age was 42.93±12.21 years with extremes ranging from 22 to 72 years. There was a male predominance with a sex ratio (M/F) of 1.56. The mean BMI of the patients was 20.70±2.87 kg/m2 with extremes from 14.45 to 28.28 kg/m2. Mean transthyretin was 0.47±0.13 g/L. Significant positive correlations were observed with albumin (r=0.77; p=0.0000) and alpha 1 glycoprotein acid (r=0.43; p= 0.004). In the absence of inflammation in the patient group, only one patient (2.44%) presented with hypotranthyretinemia. Conclusion: Transthyretin provides quantitative and clinically useful data for better management of undernutrition and, above all, for predicting the morbidity and mortality associated with protein-energy undernutrition.
    
    VL  - 11
    IS  - 4
    ER  - 

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Author Information
  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

  • Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

  • Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

  • Nephrology-Dialysis Department, Souro Sanou University Hospital, Bobo-Dioulasso, Burkina Faso

  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Department of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy and Dentistry, Cheikh Anta Diop University, Dakar, Senegal

  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Higher Institute of Health Sciences (IN. S. SA), Nazi Boni University, Bobo-Dioulasso, Burkina-Faso

  • Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

  • Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

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