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Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats

Received: 19 March 2020     Accepted: 11 May 2020     Published: 23 February 2021
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Abstract

Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.

Published in Advances in Biochemistry (Volume 9, Issue 1)
DOI 10.11648/j.ab.20210901.12
Page(s) 6-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Ameliorative, Diabetes, Leaf Extract, Medicinal Plants, Moringa oleifera, Streptozocin, Wistar Rats

References
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[2] Paari, E., & Pari, L., Role Of Some Phytochemicals In The Management Of Diabetes Mellitus: A Review.. Journal of Medical Practice and Review 2019 3 (04).
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[4] Chattopadhyay, S., Samanta, S., Ganguly, S., Banerjee, J., & Chanda, R., Types, Causes, Effect and Common Treatment of Diabetic Mellitus (DM), A Long Term Endocrine Metabolic Disorder:. A Review. Sustainable Humanosphere,, 2020 16 (1): p. 416-424.
[5] McIntyre, H. D., Sacks, D. A., Barbour, L. A., Feig, D. S., Catalano, P. M., Damm, P., & McElduff, A., Issues with the diagnosis and classification of hyperglycemia in early pregnancy.. Diabetes care 2016. 39 (1): p. 53-54.
[6] Pinheiro, M. M., Pinheiro, F. M. M., & Trabachin, M. L., Dipeptidyl peptidase-4 inhibitors (DPP-4i) combined with vitamin D3: An exploration to treat new-onset type 1 diabetes mellitus and latent autoimmune diabetes in adults in the future International immunopharmacology 2018. 57: p. 11-17.
[7] Pasquel, F. J., Tsegka, K., Wang, H., Cardona, S., Galindo, R. J., Fayfman, M.,... & Narayan, K. V., Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study. 349-357. Diabetes Care 2020. 43 (2).
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[10] El Rabey, H. A., Khan, J. A., Sakran, M. I., & Al-Ghamdi, M. A., The Antioxidant Activity of Low Doses of Moringa Seeds (Moringa oleifera Lam.) in Hypercholesterolemic Male Rats Reactive Oxygen Species 2018 6 (17): p. 363-370.
[11] Farid, A. S., & Hegazy, A. M., Ameliorative effects of Moringa oleifera leaf extract on levofloxacin-induced hepatic toxicity in rats Drug and chemical toxicolog 2019 48 (1): p. 345-55.
[12] Vergara-Jimenez, M., Almatrafi, M. M., & Fernandez, M. L., Bioactive components in Moringa Oleifera leaves protect against chronic disease. Antioxidants 2017 6 (4): p. 91.
[13] Huang, Q., Zhao, W., Yan, A., & Zhang, W., Applications of Reference Eextract in Determining the Characteristic Spectrum of Ginkgo Leaf Preparations.. Herald of Medicine,, 2017.. 36 (7): p. 794-797.
[14] Mostafavinia, A., Amini, A., Ghorishi, S. K., Pouriran, R., & Bayat, M., The effects of dosage and the routes of administrations of streptozotocin and alloxan on induction rate of typel diabetes mellitus and mortality rate in rats.. Laboratory animal research,, 2016. 32 (3): p. 160-165.
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Cite This Article
  • APA Style

    Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2021). Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Advances in Biochemistry, 9(1), 6-10. https://doi.org/10.11648/j.ab.20210901.12

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    ACS Style

    Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Adv. Biochem. 2021, 9(1), 6-10. doi: 10.11648/j.ab.20210901.12

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    AMA Style

    Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats. Adv Biochem. 2021;9(1):6-10. doi: 10.11648/j.ab.20210901.12

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  • @article{10.11648/j.ab.20210901.12,
      author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Aliyu Habeeb Tosin and Nicholas Nathaniel Pilau and Adamu Abdul Abubakar and Muhammad Bashir Bello Muhammad Bashir Bello},
      title = {Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats},
      journal = {Advances in Biochemistry},
      volume = {9},
      number = {1},
      pages = {6-10},
      doi = {10.11648/j.ab.20210901.12},
      url = {https://doi.org/10.11648/j.ab.20210901.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20210901.12},
      abstract = {Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.},
     year = {2021}
    }
    

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    T1  - Ameliorative Effect of Moringa Oleifera Biochemical Constituents on Blood Glucose Level of Streptozocin-Induced Diabetic Wistar Rats
    AU  - Ibrahim Maina Hassan
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    AU  - Adamu Abdul Abubakar
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    DO  - 10.11648/j.ab.20210901.12
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
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    AB  - Medicinal plants are among the important source of potential therapeutic agents for diabetes. Therapeutic use of Moringa oleifera leaf extract has been practiced in management of diabetes because of its potential to decrease blood glucose and lipids concentration after ingestion. This study was conducted to evaluate the ameliorative effect of Moringa oleifera leaf extract on streptozocin induced diabetes Wistar rats. Initially, diabetes was induced by given streptozocin (STZ) intravenously followed by the treatments with different concentration of Moringa oleifera aqueous leaf extract. Fasting blood glucose level was measured using Accu-Chek glucometer after 24, 48, 72 and 97 hours post treatment. There is significance difference at 0.05 in blood glucose level between the control groups and the groups that were treated with the leaf extract after administration of STZ. Hence, this plant shows high potential to be used in the management of hyperglycaemia. The need for the toxicity study to evaluate it effect in body tissues and organs is recommended. There is need to study the phytochemical constituents to identify the bioactive lead compound with ameliorative effect.
    VL  - 9
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Author Information
  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Medicine, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

  • Department of Veterinary Microbiology, Faculty of Veterinary Medicine, Usmanu Danfodiyo University, Sokoto, Nigeria

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