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Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats

Received: 27 July 2019     Accepted: 18 August 2019     Published: 26 August 2019
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Abstract

This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg-1), catechin only (CT) at 40mg kg-1, As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg-1 (1/20th LD50), As+DM-CT40 treated as As+DM in addition to oral administration of CT at 40mg kg-1 while the last group, As+DM-CT80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg-1. The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.

Published in Advances in Biochemistry (Volume 7, Issue 2)
DOI 10.11648/j.ab.20190702.12
Page(s) 51-58
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Arsenic, Deltamethrin, Oxidative Stress, Inflammation, Catechin

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  • APA Style

    Afolabi Olusegun Kayode, Arinola Abimbola, Aderibigbe Felix Adesola, Folarin Dasola Teslim, Wusu Adedoja Dorcas. (2019). Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats. Advances in Biochemistry, 7(2), 51-58. https://doi.org/10.11648/j.ab.20190702.12

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    ACS Style

    Afolabi Olusegun Kayode; Arinola Abimbola; Aderibigbe Felix Adesola; Folarin Dasola Teslim; Wusu Adedoja Dorcas. Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats. Adv. Biochem. 2019, 7(2), 51-58. doi: 10.11648/j.ab.20190702.12

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    AMA Style

    Afolabi Olusegun Kayode, Arinola Abimbola, Aderibigbe Felix Adesola, Folarin Dasola Teslim, Wusu Adedoja Dorcas. Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats. Adv Biochem. 2019;7(2):51-58. doi: 10.11648/j.ab.20190702.12

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  • @article{10.11648/j.ab.20190702.12,
      author = {Afolabi Olusegun Kayode and Arinola Abimbola and Aderibigbe Felix Adesola and Folarin Dasola Teslim and Wusu Adedoja Dorcas},
      title = {Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats},
      journal = {Advances in Biochemistry},
      volume = {7},
      number = {2},
      pages = {51-58},
      doi = {10.11648/j.ab.20190702.12},
      url = {https://doi.org/10.11648/j.ab.20190702.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20190702.12},
      abstract = {This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg-1), catechin only (CT) at 40mg kg-1, As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg-1 (1/20th LD50), As+DM-CT40 treated as As+DM in addition to oral administration of CT at 40mg kg-1 while the last group, As+DM-CT80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg-1. The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Catechin Attenuates the Effect of Combined Arsenic and Deltamethrin Toxicity by Abrogation of Oxidative Stress and Inflammation in Wistar Rats
    AU  - Afolabi Olusegun Kayode
    AU  - Arinola Abimbola
    AU  - Aderibigbe Felix Adesola
    AU  - Folarin Dasola Teslim
    AU  - Wusu Adedoja Dorcas
    Y1  - 2019/08/26
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    N1  - https://doi.org/10.11648/j.ab.20190702.12
    DO  - 10.11648/j.ab.20190702.12
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 51
    EP  - 58
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20190702.12
    AB  - This study was aimed at evaluating the protective role of catechin (CT) against toxicity induced by combined exposure to arsenic (As) and deltamethrin (DM) in rats. Thirty-five (35) male Wistar rats were divided into 5 groups of 7 animals each. Treatment of each group was as follows: Control (C) administered corn oil (1ml kg-1), catechin only (CT) at 40mg kg-1, As+DM administered As (100ppm) in their drinking water and DM at a dose of 7.5mg kg-1 (1/20th LD50), As+DM-CT40 treated as As+DM in addition to oral administration of CT at 40mg kg-1 while the last group, As+DM-CT80 received the same treatment as As+DM, along with oral CT treatment at a dose of 80mg kg-1. The treatment lasted for 28 days. Effect of the treatment in inducing oxidative damage was appraised by estimating levels of lipid peroxidation, protein oxidation, glutathione and total antioxidant capacity in the liver, kidney, and testis of the rats. Also, the activities of superoxide dismutase, catalase, and glutathione peroxidase were assayed in the tissues. For the evaluation of inflammation, plasma levels of interleukin-6, tumor necrosis factor-alpha and 8-nitroguanine were determined. The result showed that the combination of As and DM gave rise to marked alterations of these parameters but supplementation with CT attenuated these effects.
    VL  - 7
    IS  - 2
    ER  - 

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Author Information
  • Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

  • Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

  • Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

  • Department of Biochemistry, Faculty of Basic Medical Sciences, Ladoke Akintola University of Technology, Ogbomoso, Nigeria

  • Department of Biochemistry, Faculty of Science, Lagos State University, Ojo, Lagos

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