Aspirin is the most extensively used mild analgesic and antipyretic drug. In Libya as well as worldwide, aspirin is purchased without prescription in many forms and is imported into the country without any control. However, conditions for packing, storing and preventing the drug from damage are not properly followed. There are no supervision or quality control procedures on the validity and chemical composition of the drug. In this study, thirteen available aspirin forms imported from different countries and one sample from local factory were collected and analyzed for comparison. The quality of the samples was examined in terms of active ingredient (acetyl salicylic acid- ASA), toxic heavy metal and salicylic acid impurities. ASA contents were analyzed using volumetric titration and HPLC method. The toxic heavy metal impurities were determined using atomic absorption spectrophotometry, and salicylic acid impurity was determined by fluorimetric method. The active ASA contents were found in the range from 87 to 104%. Comparison of the determined ASA contents with the actual contents per tablet indicated that only 14% of the samples were in identical values, whereas; 57.1% were exceeded and 28.6% were less than the actual content per tablet. The salicylic acid impurities were under permissible limit. Although, the results for the toxic heavy metals impurities showed significant variations among the samples, but all were under the limit permitted by the world health organization.
| Published in | Advances in Biochemistry (Volume 3, Issue 1) |
| DOI | 10.11648/j.ab.20150301.13 |
| Page(s) | 9-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
Aspirin, Salicylic Acid, Acetylsalicylic Acid, Toxic Heavy Metal, Atomic Absorption Spectroscopy, HPLC
| [1] | American Heart Association (2008). Aspirin in Heart Attack and Stroke Prevention. http://www.americanheart.org/presenter.jhtmlidentifier4456 |
| [2] | Aukerman, G., Knutson, D., Miser, W.F., 2000. Management of the acute migraine headache. American Family and Physician, 66 (11), 2123–30. |
| [3] | Borzak, S., Cannon, C.P., Kraft, P.L., Douthat, L., Becker, R.C., Palmeri, S.T., Henry, T., Hochman, J.S., Fuchs, J., Antman, E.M., McCabe, C., Braunwald, E., 1998. Effects of Prior Aspirin and Anti-Ischemic Therapy on Outcome of Patients with Unstable Angina. American Journal Cardiology, 81(6), 678-681. |
| [4] | Brambilla, M., Parolari, A., Camera, M., Colli, S., Eligini, S., Centenaro, C., Anselmo, A., Alamanni, F., Tremoli, E., 2010. Effect of two doses of aspirin on thromboxane biosynthesis and platelet function in patients undergoing coronary surgery. Thrombosis Haemostasis, 2010, 103(3), 516-24. |
| [5] | Cham, E. B., Lesley, R.L., Felix, B., Imhoff, D. M., 1980. Measurement and Pharmacokinetics of Acetylsalicylic Acid by a Novel High Performance Liquid Chromatographic Assay. Therapeutic drug monitoring, 2, 365-372. |
| [6] | Cheng, T.O., 2007. The History of Aspirin. Texas Heart Institute Journal, 34(3), 392–393. |
| [7] | Endo, H, Sakai, E, Kato, T, Umezawa, S, Higurashi, T, Ohkubo, H, Nakajima, A., 2014. Small bowel injury in low-dose aspirin users. Journal Gastroenterology, Dec 14. [Epub ahead of print] |
| [8] | Franeta, J.T., Agbaba, D., Eric, S., Pavkov, S. Aleksic, M., and Vladimiro, S., 2002. HPLC assay of acetylsalicylic acid, paracetamol, caffeine, and Phenobarbital in tablets. II Farmaco, 57(9), 709-713. |
| [9] | Iskander, F.Y., Klein, D. E., Bauer, T. L., 1986. Determination of trace element impurities in aspirin tablets by neutron activation analysis, Journal of Radio Analytical and Nuclear Chemistry, 97 (2), 353-357 |
| [10] | Jeffreys, D., 2005. Aspirin: The Remarkable Story of a Wonder Drug. Bloomsbury USA. pp.73-269. |
| [11] | Juhl, W. E., and Kirchhoefer, R. D., 1980. Aspirin - a national survey I: Semiautomated determination of aspirin in bulk and tablet formulations and salicylic acid in tablet formulations. Journal Pharmaceutical Sciences, 69(5), 544-548. |
| [12] | Kirchhoefer, R. D., and Juhl, W. E. 1980. Aspirin- a national survey II: determination of salicylic acid in bulk aspirin and aspirin formulation by high-pressure liquid chromatography using a fluorescence detector. Journal Pharmaceutical Sciences, 69(5), 544-548. |
| [13] | Krumholz, H. M., Radford, M. J., Ellerbeck, E.F., Hennen, J., Meehan, T.P., Petrillo, M., Wang, Y., Kresowik, T.F., Jencks, S. F., 1995. Aspirin in the Treatment of Acute Myocardial Infarction in Elderly Medicare Beneficiaries: Patterns of Use and Outcomes. Circulation, 92 (10), 2841–2847 |
| [14] | Marcus, A.J., Broekman, M.J., 1998. Aspirin analogs as antithrombotic agents. Journal of Laboratory and Clinical Medicine, 132 (6), 446-447 |
| [15] | Miyoshi, E., Saiki, K., 2009. Trace element impurity determination in aspirin tablets by INAA Journal of Radio Analytical and Nuclear Chemistry, 280 (2) 299-301. |
| [16] | Moysich, K.B., Menezes, R.J., Ronsani, A., 2002) Regular aspirin use and lung cancer risk. BMC Cancer, 2, pp. 31. |
| [17] | Reynolds, E. F., (ed) (1982). Aspirin and similar analgesic and anti-inflammatory agents. Martindale, The Extra Pharmacopoeia 28 Ed, pp.234-82. |
| [18] | Rodrigues, A. Jr., Vila Marta, M.D.C., and Tubino, M., 2004. Acetylsalicylic Acid Determination in Remedies Using a Gas-Diffusion Flow Injection Analysis (2). Journal of Flow Injection Analysis, 21(1), 25-27. |
| [19] | Salako, Q., Fadiran, E.O., Thomas, W.O., 1989. Detection and determination of salicylic acid impurity in aspirin tablet formulation by HPLC. African Journal of Medicine and Medical Sciences 18(3), 215-218. |
| [20] | Smith, J.P., Haddad, E.V., Taylor, M.B., Oram, D., Blakemore, D., Chen, Q., Boutaud, O., Oates, J.A. 2012. Suboptimal inhibition of platelet cyclooxygenase-1 by aspirin in metabolic syndrome. Hypertension, 59(3), 719-25. |
| [21] | Tang, S.Y., Sivakumar, M., Ng, A.M., Shridharan, P. 2012. Anti-inflammatory and analgesic activity of novel oral aspirin-loaded nanoemulsion and nano multiple emulsion formulations generated using ultrasound cavitation. International Journal Pharmmaceutics, 430(1-2), 299-306. |
| [22] | Temple, A. R., 1981. Acute and chronic effects of aspirin toxicity and their treatment. Archive of Internal Medicine, 141 (3), 364–9. |
| [23] | White, C. E., Weissler, A., (1972). Fluorometric analysis, Analytical Chemistry, 44, 182–206. |
| [24] | WHO. The international Pharmacopeia (2011) |
| [25] | Yang, D., Pinyupa, P., Nuwat, V., and Soravoot, R., 2004. Quality of pharmaceutical items available from drug stores in Phnom Penh, Cambodia 35(3), 741-747. |
APA Style
Somaya Al-Sadeq Al-Taeb, Khairi Al-Sadeq Ahmed Al-Tayeb, Abdussalam Salem Al-Aseer, Mohammad Mushahid Khan. (2015). Atomic Absorption Analysis of Toxic Heavy Metal Impurities in Various Commercial Aspirin Formulations. Advances in Biochemistry, 3(1), 9-14. https://doi.org/10.11648/j.ab.20150301.13
ACS Style
Somaya Al-Sadeq Al-Taeb; Khairi Al-Sadeq Ahmed Al-Tayeb; Abdussalam Salem Al-Aseer; Mohammad Mushahid Khan. Atomic Absorption Analysis of Toxic Heavy Metal Impurities in Various Commercial Aspirin Formulations. Adv. Biochem. 2015, 3(1), 9-14. doi: 10.11648/j.ab.20150301.13
AMA Style
Somaya Al-Sadeq Al-Taeb, Khairi Al-Sadeq Ahmed Al-Tayeb, Abdussalam Salem Al-Aseer, Mohammad Mushahid Khan. Atomic Absorption Analysis of Toxic Heavy Metal Impurities in Various Commercial Aspirin Formulations. Adv Biochem. 2015;3(1):9-14. doi: 10.11648/j.ab.20150301.13
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author = {Somaya Al-Sadeq Al-Taeb and Khairi Al-Sadeq Ahmed Al-Tayeb and Abdussalam Salem Al-Aseer and Mohammad Mushahid Khan},
title = {Atomic Absorption Analysis of Toxic Heavy Metal Impurities in Various Commercial Aspirin Formulations},
journal = {Advances in Biochemistry},
volume = {3},
number = {1},
pages = {9-14},
doi = {10.11648/j.ab.20150301.13},
url = {https://doi.org/10.11648/j.ab.20150301.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20150301.13},
abstract = {Aspirin is the most extensively used mild analgesic and antipyretic drug. In Libya as well as worldwide, aspirin is purchased without prescription in many forms and is imported into the country without any control. However, conditions for packing, storing and preventing the drug from damage are not properly followed. There are no supervision or quality control procedures on the validity and chemical composition of the drug. In this study, thirteen available aspirin forms imported from different countries and one sample from local factory were collected and analyzed for comparison. The quality of the samples was examined in terms of active ingredient (acetyl salicylic acid- ASA), toxic heavy metal and salicylic acid impurities. ASA contents were analyzed using volumetric titration and HPLC method. The toxic heavy metal impurities were determined using atomic absorption spectrophotometry, and salicylic acid impurity was determined by fluorimetric method. The active ASA contents were found in the range from 87 to 104%. Comparison of the determined ASA contents with the actual contents per tablet indicated that only 14% of the samples were in identical values, whereas; 57.1% were exceeded and 28.6% were less than the actual content per tablet. The salicylic acid impurities were under permissible limit. Although, the results for the toxic heavy metals impurities showed significant variations among the samples, but all were under the limit permitted by the world health organization.},
year = {2015}
}
TY - JOUR T1 - Atomic Absorption Analysis of Toxic Heavy Metal Impurities in Various Commercial Aspirin Formulations AU - Somaya Al-Sadeq Al-Taeb AU - Khairi Al-Sadeq Ahmed Al-Tayeb AU - Abdussalam Salem Al-Aseer AU - Mohammad Mushahid Khan Y1 - 2015/02/06 PY - 2015 N1 - https://doi.org/10.11648/j.ab.20150301.13 DO - 10.11648/j.ab.20150301.13 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 9 EP - 14 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20150301.13 AB - Aspirin is the most extensively used mild analgesic and antipyretic drug. In Libya as well as worldwide, aspirin is purchased without prescription in many forms and is imported into the country without any control. However, conditions for packing, storing and preventing the drug from damage are not properly followed. There are no supervision or quality control procedures on the validity and chemical composition of the drug. In this study, thirteen available aspirin forms imported from different countries and one sample from local factory were collected and analyzed for comparison. The quality of the samples was examined in terms of active ingredient (acetyl salicylic acid- ASA), toxic heavy metal and salicylic acid impurities. ASA contents were analyzed using volumetric titration and HPLC method. The toxic heavy metal impurities were determined using atomic absorption spectrophotometry, and salicylic acid impurity was determined by fluorimetric method. The active ASA contents were found in the range from 87 to 104%. Comparison of the determined ASA contents with the actual contents per tablet indicated that only 14% of the samples were in identical values, whereas; 57.1% were exceeded and 28.6% were less than the actual content per tablet. The salicylic acid impurities were under permissible limit. Although, the results for the toxic heavy metals impurities showed significant variations among the samples, but all were under the limit permitted by the world health organization. VL - 3 IS - 1 ER -
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