| Peer-Reviewed

Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola

Published: 2 April 2013
Views:       Downloads:
Abstract

The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.

Published in Advances in Biochemistry (Volume 1, Issue 1)
DOI 10.11648/j.ab.20130101.11
Page(s) 1-4
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2013. Published by Science Publishing Group

Previous article
Keywords

Garcinia kola, Saponin, lipid profile, tissue, dose dependent, Hyperlipidemia

References
[1] E. A. Sofowora . Medicinal plant and traditional medicine in Africa. John Wiley and sons LTD. 2008; Pp.1-10.
[2] Akinmoladun, E. O. Ibukun, E. M. Obuotor, and E. O. Farombi. Phytochemical constituent and antitoxidant activity of extract from leaves Ocimum gratissimum, Science Research Essay. 2007; Vol. 2:163-166
[3] Onyeneke E.C, Adebisi KE, Eriyamremu GE, Ojeaburu SI, Asagba SO, Oluba OM . Effect of lipid-based diet on some lipid-metabolizing enzymes. J. Med. Sci.,2007; 7(8): 1283-1289.
[4] Oluba OM, Adeyemi O, Ojieh GC, Adebisi KE, Isiosio IO, Aboluwoye CO (2008a). Effect of dietary cholesterol on some serum enzymes. J. Med. Sci., 2008; 8(4): 390-394.
[5] Siddiqui, AA., Wani, SM., Rajesh, R. and Alargarsamy R. Phytochemical and pharmacological investigation of Hibiscus rosa sinensis Linn. Indian Journal of
[6] pharmaceutical sciences.2006; 68(5):588-593
[7] Kitagawa, I., Saito, M. And Yoshihawa, M. Structure of soyaponin A, a bisdesmoside of soya sapogenol A from soyabean, the seeds of Glycine max Merril. Chemical and Pharmaceutical Bulletin. 1985; 33: 1069-1072.
[8] Khalil, A.H and El-Adawy, T.A. Isolation, Identification and toxicity of Saponin from different legumes. Food Chemistry. 1994; 50: 197-201.
[9] Richmond, W. Preparation and properties of a cholesterol oxidase from nocardia sp. And its application to the enzymatic assay of total cholesterol in serum.Clin.Chem.1973; 19(12): 1350-1356
[10] Jacobs, D.S, Kasten , B.L ; De Mott, W.R ; Wolfson, W.L. In laboratory and Test Handbook; Eds ; Lexi-comp Inc: Hudson, Cleveland.1990; p. 219.
[11] Fossati, P., Precipe, L. Serum triglycerides determined colorimetrically with an enzyme that produces hydrogen peroxide. Clin. Chem. 1982; 28: 2007-2080
[12] Friedewald WT, Levy RRI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin. Chem.1972; 18: 499 –502.
[13] Ibraheim ZZ. Effect of Nigella sativa seeds and total oil on some blood parameters in female doxorubicin volunteers. Saudi Pharm. J. 2002; 10: 54–59.
[14] Zaoui A, Cherrah Y, Alaoui K, Mahassine N, Amarouch H, Hassar M. Effects of Nigella sativa fixed oil on blood homeostasis in rat. J. Ethnopharmacol. 2002b; 79 (1): 23-6.
[15] El-Dakhakhny M, Mady NI, Halim MA. Nigella sativa L. Oil protects against induced hepatotoxicity and improves serum lipid profile in rats. ARZNEIMITTEL. FORSCH. 2000; 50 (9): 832-6.
[16] Le PM, Benhaddou-Andaloussi A, Elimadi A, Settaf A, Cherrah Y, Haddad PS. The petroleum ether extract of Nigella sativa exerts lipid-lowering and insulin-sensitizing actions in the rat. J. Ethnopharmacol. 2004; 94: 251-9.
[17] Khanna, A.R.F. Rizvi and R. Chander. Lipid lowering activity of phyllanthus niruri in hyperlipidemia rats . J. Ethnoparmacol. 2002; 82: 19-22.
[18] Oyetayo, F.L. Responses of Plasma lipids to edible Mushroom diets in albino rats .Afri. J. Biotechnol 2006; 1263-1266.
Cite This Article
  • APA Style

    Alli Smith Y. R., Adanlawo I. G. (2013). Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Advances in Biochemistry, 1(1), 1-4. https://doi.org/10.11648/j.ab.20130101.11

    Copy | Download

    ACS Style

    Alli Smith Y. R.; Adanlawo I. G. Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Adv. Biochem. 2013, 1(1), 1-4. doi: 10.11648/j.ab.20130101.11

    Copy | Download

    AMA Style

    Alli Smith Y. R., Adanlawo I. G. Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Adv Biochem. 2013;1(1):1-4. doi: 10.11648/j.ab.20130101.11

    Copy | Download

  • @article{10.11648/j.ab.20130101.11,
      author = {Alli Smith Y. R. and Adanlawo I. G.},
      title = {Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola},
      journal = {Advances in Biochemistry},
      volume = {1},
      number = {1},
      pages = {1-4},
      doi = {10.11648/j.ab.20130101.11},
      url = {https://doi.org/10.11648/j.ab.20130101.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130101.11},
      abstract = {The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.},
     year = {2013}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola
    AU  - Alli Smith Y. R.
    AU  - Adanlawo I. G.
    Y1  - 2013/04/02
    PY  - 2013
    N1  - https://doi.org/10.11648/j.ab.20130101.11
    DO  - 10.11648/j.ab.20130101.11
    T2  - Advances in Biochemistry
    JF  - Advances in Biochemistry
    JO  - Advances in Biochemistry
    SP  - 1
    EP  - 4
    PB  - Science Publishing Group
    SN  - 2329-0862
    UR  - https://doi.org/10.11648/j.ab.20130101.11
    AB  - The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.
    VL  - 1
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria

  • Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria

  • Sections