Objective: To study the dynamic changes of pupil diameter and the related influencing factors in type 1 diabetes mellitus under different light intensities. Methods: Fifty cases of type 1 diabetes patients diagnosed in the endocrinology department and corresponding healthy subjects in the physical examination department were randomly selected as the control group. The inclusion criteria were based on international classification criteria. The fluorescein sodium fundus angiography showed no obvious retinopathy and non-proliferate diabetic retinopathy. Type 1 diabetes patients. All patients underwent the French VX120 anterior segment analyzer to measure the pupil diameter of the eye in darkroom conditions, and collected glycosylated hemoglobin (IFCC), glycated albumin, diabetes course, 24h urine protein and 24h urine glucose data. Analyze the correlation between ΔY1 (the pupil diameter change from scotopic to low), ΔY2 (the pupil diameter change from low to mesopic), ΔY3 (the pupil diameter change from mesopic to photopic) and other parameters. Results: The average age of the case group was 39.60±14.47 years old. The average age of the normal control group was 32.90±8.16 years. There was no significant difference between the two groups (P>0.05) (P=0.05). The average glycated hemoglobin (IFCC) of the case group was 75.70±16.34 mmol•mol^-1. The group averaged glycated hemoglobin (IFCC) was 42.80±4.16 mmol•mol -1; the difference between the two groups was statistically significant (P<0.05) (p=0.0001), the average glycated albumin was 29.11±9.46%, and the control group was averaged glycated albumin 18.15±4.33%. The difference was statistically significant (P<0.05) (P=0.0037). There was no statistical difference between ΔY2 and ΔY3 and other parameters. There was a correlation between ΔY1 and glycosylated hemoglobin. The correlation coefficient was R=-0.646, P=0.044. The regression equation was ΔY1=4.172-0.031X. Conclusion: The changes of glycated hemoglobin and pupil diameter Negative correlation, detection of glycosylated hemoglobin in patients with type 1 diabetes, can assess the pupil diameter of the patient's eye and prevent cardiovascular complications in time.

Type 1 Diabetes, VX120, Pupil Diameter Change